What is a P504S antibody?
P504S, also known as α-methylacyl coenzyme A racemase (AMACR), is a peroxisomal and mitochondrial enzyme that plays a role in bile acid synthesis and β-oxidation of branched chain fatty acids.
What does P504S stain?
P504S stains the vast majority of prostate cancers, and P504S has been shown to stain numerous other tumor types, such as hepatoma, breast carcinoma, pancreatic islet tumor and desmoplastic small round cell tumor.
What is a Gleason pattern?
Gleason pattern 1 is the most well-differentiated tumor pattern. It is a well-defined nodule of single/separate, closely/densely packed, back-to-back gland pattern that does not invade into adjacent healthy prostatic tissue.
What does a P504S positive mean?
Expression of P504S was not found in basal cell hyperplasia, urothelial cells/metaplasia and small atrophic glands that may mimic prostate carcinoma. Our findings indicate that P504S is a highly sensitive and specific positive marker for prostate carcinoma.
What is Racemase staining?
Positive racemase staining converts an atypical diagnosis, based on suspicious histology and negative basal cell marker stains, to cancer in approximately 10% of cases thought to be atypical by contributing pathologists, and in approximately 50% of cases thought to be atypical by a specialist in genitourinary pathology …
What is the life expectancy with a Gleason score of 7?
Maximum estimated lost life expectancy for men with Gleason score 5 to 7 tumors was 4 to 5 years and for men with Gleason score 8 to 10 tumors was 6 to 8 years.
Can a Gleason score go down?
The decrease in proportion of high Gleason score cancers, however, was due to higher rates of low-grade disease diagnosis as a result of PSA screening. The researchers show that the shift in Gleason score proportions over time is not likely due to changes in the age at diagnosis.
What is focal high grade prostatic intraepithelial neoplasia?
HGPIN refers to proliferation of prostate glandular epithelial cells that display significant cytological atypia within the confines of prostatic ducts and acini. 2. It has been accepted as the main precursor lesion to invasive prostate carcinoma.
What does positive for Racemase mean?
What does AMACR positive mean?
Alpha-methylacyl-CoA-racemase (AMACR) is a recently discovered tumor marker whose expression is significantly upregulated in prostate cancer.
Is Gleason 7 serious?
A Gleason score of 7 is a medium-grade cancer, and a score of 8, 9, or 10 is a high-grade cancer. A lower-grade cancer grows more slowly and is less likely to spread than a high-grade cancer. Doctors look at the Gleason score in addition to stage to help plan treatment.