What is the difference between fructosamine and HbA1c?
HbA1c and fructosamine are highly correlated. The relationship between the fructosamine level and the HbA1c level can be present as a linear regression analysis, as follows: HbA1c = 0.017 X fructosamine level (µmol/L) + 1.61.
Why do we use fructosamine instead of HbA1c?
HbA1c is most frequently used being a very reliable marker. Fructosamine may be useful in situations where HbA1c cannot be reliably measured however measurement is not standardised meaning no reference intervals can be recommended and one laboratory’s results can be compared to another.
What is glycated albumin?
The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels. GA is the higher glycated portion of fructosamine. It is measured by a standardized enzymatic methodology, easy and fast to perform.
When do you use fructosamine instead of A1c?
Fructosamine testing may be used to help people with diabetes monitor and control their blood glucose levels in cases where the A1c test cannot be used and/or a shorter-term monitoring window is desired. The level of fructosamine in the blood is a reflection of glucose levels over the previous 2-3 weeks.
Is fructosamine more accurate than A1C?
The American Diabetes Association (ADA) recognizes the utility of both tests, and says that fructosamine may be a better choice when A1C cannot be reliably measured.
Is A1C the same as fructosamine?
A serum fructosamine (a glycated protein) level, similar to a hemoglobin A1c (HbA1c) level, enables assessment of long-term glycemic control in patients with diabetes mellitus.
Is fructosamine more accurate than A1c?
What is the relationship between the HbA1c blood test and diabetic control?
HbA1c is an important indicator of long-term glycemic control with the ability to reflect the cumulative glycemic history of the preceding two to three months. HbA1c not only provides a reliable measure of chronic hyperglycemia but also correlates well with the risk of long-term diabetes complications.
How is glycated albumin measured?
In the assay, glycated albumin is hydrolyzed to glycated amino acids by proteinase digestion, and ketoamine oxidase oxidizes the glycated amino acids to produce hydrogen peroxide, which is quantitatively measured. Glycated albumin is calculated as the percentage of glycated albumin in total albumin.
How accurate is fructosamine?
In a cross-sectional and longitudinal study including 10 987 subjects, Malmström and colleagues showed that fructosamine was effective in discriminating subjects with and without diabetes (AUC, 0.95), displaying 0.61 sensitivity and 0.97 specificity at a threshold level of 2.5 mmol/L (Table 1).
How reliable is fructosamine?
What is fructosamine and glycated albumin?
Biochemistry and Biology of Fructosamine and Glycated Albumin. Human serum albumin is the most abundant extracellular protein in plasma, accounting for 60-70% of total serum proteins. It is a globular protein with a molecular mass of 67 KDa and a serum half-life of approximately 20 days.
Why is fructosamine a better index of glycemic control than A1c?
Because the half-life of albumin and other serum proteins is shorter than that of hemogloblin, concentrations of fructosamine and glycated albumin will change more rapidly than HbA1c and can serve as an index of intermediate-term glycemic control [17].
What is the mechanism of fructosamine formation?
Mechanism of fructosamine (and glycated albumin) formation. Because albumin is the most abundant of serum protein, fructosamine is predominantly a measure of GA, although other circulating proteins such as glycated lipoproteins and glycated globulins may contribute to determine the total concentration of fructosamine.
What is the difference between fructosamine and glycated amino acids (GA)?
The diagnostic efficiency of GA seems superior to that of fructosamine over a broad range of clinical settings (Table 1), and is attributable to the fact that the fructosamine reflects a total concentration of glycated serum proteins, which can fluctuate in response to a variety of systemic disorders.