How serious is metaplastic breast cancer?
Metaplastic breast cancer (MpBC) is a rare and aggressive malignancy that accounts for 0.2–5% of all breast cancers, and as such, MpBC carries the worst prognosis in comparison to other breast cancer types and plays a significant role in global breast cancer mortality [1].
What is the survival rate of metaplastic breast cancer?
For metaplastic breast cancer, the majority of published case series have demonstrated a worse prognosis than with infiltrating ductal carcinoma, even when adjusted for stage, with a 3-year overall survival rate of 48-71% and 3-year disease-free survival rate of 15-60%.
Can Metaplastic carcinoma be cured?
Metaplastic breast cancer (MpBC) is a rare type of fast-growing breast cancer that can spread anywhere in the body. Doctors often detect it in the later stages, so it is not curable, but treatment can help people manage the disease.
Does Chemo work on metaplastic breast cancer?
Chemotherapy. Chemotherapy will be recommended for many people with metaplastic breast cancer. Chemotherapy destroys cancer cells using anti-cancer drugs, and is given to reduce the risk of breast cancer returning or spreading.
How fast does metaplastic breast cancer grow?
Metaplastic breast cancer recurs more often and more quickly compared to IDC and LDC. It has a peak recurrence rate of 18 months to 3-5 years after treatment.
How is metaplastic carcinoma treated?
Metaplastic Breast Cancer Staging and Treatment Local therapy is aimed at preventing the cancer from coming back in the breast. Local therapy includes surgery (lumpectomy or mastectomy), and may include radiation. Systemic therapy is used to prevent the disease from coming back or spreading to another part of the body.
What causes Metaplastic carcinoma?
According to the National Institutes of Health (NIH), there are no known inherited genetic predisposing risk factors for metaplastic breast cancer. The cause for this type of cancer is not known. Known risk factors for any breast cancer include: age — most breast cancers are diagnosed after age 50.
Is Metaplastic carcinoma invasive?
Metaplastic breast cancer is a rare type of breast cancer accounting for around 1% of breast cancers. Metaplastic breast cancer is an invasive cancer, which means it has the potential to spread to other parts of the body.
What is the best treatment for metaplastic breast cancer?
What is metaplastic carcinoma of the breast?
Metaplastic carcinoma of the breast is a rare condition. The exact prevalence is not known. While estimates vary, it is thought to account for less than 1% of all breast cancers. [2] In the broad sense, metaplastic carcinoma of the breast is also genetic. All cancers involve genetic changes in affected cells.
How are metaplastic carcinomas classified?
The metaplastic carcinomas were classified according to the World Health Organization classification.
What are the markers of metaplastic breast carcinoma?
Metaplastic breast carcinomas are enriched in markers of tumor-initiating cells and epithelial to mesenchymal transition. Mod Pathol. 2012;25:178–184. doi: 10.1038/modpathol.2011.167.
Is metaplastic carcinoma more aggressive than invasive ductal carcinoma or lobular carcinoma?
In conclusion, the results of this study clearly demonstrated that metaplastic carcinoma is more aggressive than invasive ductal carcinoma or invasive lobular carcinoma.