What is omentin 1?
Omentin-1 is a glucoprotein of the adiponectin family released from visceral adipose tissue, endothelial cells, and visceral fat stromal–vascular cells. It has anti-inflammatory effect and circulating omentin-1 concentration correlates negatively with waist circumference, insulin resistance, and body-mass index.
Does dietary intake impact omentin gene expression and plasma concentration a systematic review?
A high-fat diet (HFD) was shown to reduce omentin gene expression in one animal study. In the observational studies, omentin serum concentration was reduced by Ramadan fasting and saturated fatty acid (SFA) intake, and an increase in omentin gene expression was observed with monounsaturated fatty acid (MUFA) intake.
What is the function of resistin?
resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. As a result, the liver is less able to clear ‘bad’ cholesterol from the body. Resistin accelerates the accumulation of LDL in arteries, increasing the risk of heart disease.
Is leptin an Adipokine?
Leptin is a pleiotropic adipokine with diverse effects on cell types throughout the body. Its role in neuroendocrine signaling, homeostasis, and metabolism has been well studied.
Is IL 6 an Adipokine?
In addition to leptin, TNF and IL-6, more recently identified adipokines that promote inflammation include resistin, retinol-binding protein 4 (RbP4), lipocalin 2, IL-18, angiopoietin-like protein 2 (ANGPTL2), CC-chemokine ligand 2 (CCL2), CXC-chemokine ligand 5 (CXCL5) and nicotinamide phospho ribosyltransferase ( …
Does resistin cause diabetes?
Resistin is involved in insulin resistance and links obesity to diabetes in mice; it is involved in inflammation in humans. Resistin is exclusively expressed in white adipose tissue in rodents. On the other hand, it is expressed and secreted in macrophages in humans.
Is IL 6 an adipokine?
Do adipocytes produce IL-6?
Conclusions: IL-6 is produced by human adipocytes and is a potential marker of adipocyte differentiation. Furthermore it is a hormonally regulated cytokine, suppressed by glucocorticoids, and stimulated by catecholamines and insulin in physiological concentrations.
What is omentin-1 (intelectin 1)?
Omentin-1, also known as intelectin-1, is a recently identified novel adipocytokine of 313 amino acids, which is expressed in visceral (omental and epicardial) fat as well as mesothelial cells, vascular cells, airway goblet cells, small intestine, colon, ovary, and plasma. The level of omentin-1 exp …
What is circulating omentin-1 as a biomarker of obesity?
Clinical studies have indicated the usage of circulating omentin-1 as a biomarker of obesity, metabolic disorders including insulin resistance, diabetes, and metabolic syndrome, and atherosclerotic cardiovascular diseases.
What is adipose tissue-derived Omentin?
Adipose Tissue-Derived Omentin-1 Function and Regulation Omentin-1, also known as intelectin-1, is a recently identified novel adipocytokine of 313 amino acids, which is expressed in visceral (omental and epicardial) fat as well as mesothelial cells, vascular cells, airway goblet cells, small intestine, colon, ovary, and plasma.
