Is quorum sensing involved in biofilm?
Quorum sensing (QS) is a communication mechanism between bacteria that allows specific processes to be controlled, such as biofilm formation, virulence factor expression, production of secondary metabolites and stress adaptation mechanisms such as bacterial competition systems including secretion systems (SS).
How is biofilm an example of quorum sensing?
They display coordinated group behaviors regulated by quorum-sensing systems that detect the density of other bacteria around them. A key example of such group behavior is biofilm formation, in which communities of cells attach to a surface and envelope themselves in secreted polymers.
What is the role of quorum sensing to the ability of some bacteria to form biofilms?
Quorum-sensing allows individual bacteria within colonies to coordinate and carry out colony-wide functions such as: sporulation, bioluminescence, virulence, conjugation, competence and biofilm formation.
How does quorum sensing contribute to virulence in bacteria?
This process enables bacteria to express energetically expensive processes as a collective only when the impact of those processes on the environment or on a host will be maximized. Among the many traits controlled by quorum sensing is the expression of virulence factors by pathogenic bacteria.
Why is quorum sensing advantageous to bacteria?
Quorum sensing (QS) regulation allows bacteria to control their gene expression in response to their population density. The bacteria produce signaling molecules that accumulate during specific stages of growth, although their production level can also be influenced by the environment.
How do bacteria communicate in biofilms?
Many bacteria are known to regulate their cooperative activities and physiological processes through a mechanism called quorum sensing (QS), in which bacterial cells communicate with each other by releasing, sensing and responding to small diffusible signal molecules.
What types of bacteria use quorum sensing?
Gram-positive and Gram-negative bacteria use quorum sensing communication circuits to regulate a diverse array of physiological activities. These processes include symbiosis, virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
What is the relationship between biofilm development and quorum sensing?
Biofilm development and quorum sensing (QS) are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self-produced extracellular matrix. QS is a cell-cell communication mechanism that synchronizes gene expression in response to population cell density.
Do host factors affect bacterial quorum sensing during infection?
Likewise, there is evidence from transcriptomic studies that during human infection by P. aeruginosa, quorum sensing is suppressed relative to that in laboratory setups in vitro 98. These studies, although preliminary, suggest that host factors have a marked influence on bacterial quorum sensing.
What is the best book on mathematical modelling of bacterial quorum sensing?
Pérez-Velázquez, J., Gölgeli, M. & García-Contreras, R. Mathematical modelling of bacterial quorum sensing: a review. Bull. Math. Biol. 78, 1585–1639 (2016). 59. Veening, J.-W. et al. Bet-hedging and epigenetic inheritance in bacterial cell development. Proc. Natl Acad. Sci. USA 105, 4393–4398 (2008). 60.
Can surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development?
Kim, M. K. et al. Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development. Nat. Microbiol. 2, 17080 (2017). This study develops methods to coat surfaces with pro-quorum-sensing and anti-quorum-sensing compounds to manipulate bacterial group behaviours.