What is STAT3 gene?
The STAT3 gene is part of a family known as the STAT genes. These genes provide instructions for making proteins that are part of essential chemical signaling pathways within cells.
What is STAT3 in cancer?
Cancer cell-intrinsic signal transducer and activator of transcription 3 (STAT3) activity supports many of the hallmarks of cancer, including cell growth, proliferation, survival, immune evasion, metastasis and angiogenesis.
Where is STAT3 gene located?
STAT3 | ||
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Location (UCSC) | Chr 17: 42.31 – 42.39 Mb | Chr 11: 100.78 – 100.83 Mb |
PubMed search | ||
Wikidata | ||
View/Edit Human View/Edit Mouse |
What activates Stat4?
IL-12 is the major cytokine that can activate Stat4, resulting in its tyrosine phosphorylation, in both human and mouse (Leonard and O’Shea, 1998).
Is Stat5 a transcription factor?
Stat5 transcription factors are highly and broadly expressed proteins found in these cellular signaling pathways. Expression levels of Stat5 proteins vary from cell type to cell type but can reach an abundance of 3,000-100,000 molecules per cell (51).
What does the DIRAS3 gene look like?
The DIRAS3 gene includes one promoter, two exons and one intron with a 687 bp protein-coding region that encodes a 26-kDa protein. The DIRAS3 protein is a GTPase belonging to the Ras superfamily and shares 50–60% homology with Ras and Rap, two other small GTP binding proteins.
What does DIRAS3 stand for?
GTP-binding protein Di-Ras3 (DIRAS3) also known as aplysia ras homology member I (ARHI) is a protein that in humans is encoded by the DIRAS3 gene. This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers.
What happened to Gene Hackman’s acting career?
Retirement from acting. On July 7, 2004, Hackman gave a rare interview to Larry King, where he announced that he had no future film projects lined up and believed his acting career was over. In 2008, while promoting his third novel, he confirmed that he had retired from acting.
Who are Gene Hackman Dustin Hoffman and Robert Duvall?
“Gene Hackman, Dustin Hoffman, and Robert Duvall: Three Friends who Went from Rags to Riches”. Vanity Fair. Condé Nast. Retrieved September 16, 2018. ^ “VINTAGE MOVIES: “THE FRENCH CONNECTION ” “. Magnet.
https://www.youtube.com/watch?v=heCZafa_ldI