What is racecadotril medicine used for?
RACECADOTRIL is a pro-drug which breaks down into thiorphan (the active form) and works by decreasing the amount of salts and water secreted into the intestine, thereby making the stools less watery. Thus it helps in controlling the diarrhoea without interrupting change in bowel movement time.
When is the best time to take racecadotril?
Racecadotril should be taken for acute diarrhoea exactly as your doctor tells you to. It is taken three times daily at regular intervals until the diarrhoea stops (but for no longer than seven days in total). You should give the first dose as soon as possible.
Is racecadotril an antibiotic?
Racecadotril, also known as acetorphan, is an antidiarrheal medication which acts as a peripheral enkephalinase inhibitor.
How do you take racecadotril capsules?
How do I take Hidrasec? ️ Adults over 18 years of age: Take one Hidrasec 100mg capsule initially, regardless of the time of day. This should then be followed by one Hidrasec capsule taken three times a day, preferably before the main meals.
Can racecadotril be used in adults?
Clinical Uses Racecadotril is the first truly intestinal antisecretory drug to gain approval for treatment of diarrhea. The drug is available as 100 mg capsules and 10, 15 and 30 mg sachets. The recommended dosage is 100 mg three times a day for adults and 1.5 mg/kg three times a day for children.
Is racecadotril safe for babies?
There is evidence from this review that racecadotril is more effective than placebo or no intervention in reducing the duration of illness and stool output in children with acute diarrhoea and appears to be safe.
Which is better racecadotril or loperamide?
Conclusions: Racecadotril resolved the symptoms of acute diarrhoea rapidly and effectively, and produced more rapid resolution of abdominal symptoms and less constipation than loperamide.
What is the best medicine to stop diarrhea?
Two types of meds relieve diarrhea in different ways:
- Loperamide (Imodium) slows the movement of food through your intestines, which lets your body absorb more liquid.
- Bismuth subsalicylate (Kaopectate, Pepto-Bismol) balances out how fluid moves through your digestive tract.
How long does racecadotril take to work?
Uses of Racecadotril The effect of this medicine can be observed in 1 to 2 hours. The effect of this medicine lasts for an average duration of 6 to 8 hours.
How long does racecadotril stay in your system?
Racecadotril is administered by the oral route, is well absorbed from the intestinal tract and is rapidly converted to its active metabolite thiorphan. Peak plasma levels are attained in about an hour and half life of the drug is three hours.
Can I mix racecadotril with milk?
If you are taking granules for oral suspension, it should be taken directly in the mouth or mixed with a spoonful of cold or room temperature soft foods such as applesauce, carrots, rice or ice cream. You may also dissolve this medicine in a spoonful of cold or room temperature baby formula or breast milk.
Is racecadotril safe for breastfeeding?
However, since no specific clinical studies are available, racecadotril should not be administered to pregnant women. Lactation: Due to the lack of information regarding racecadotril excretion in human milk, this medicinal product should not be administered to breastfeeding women.
What is racecadotril (acetorphan)?
Racecadotril, also known as acetorphan, is an antidiarrheal medication which acts as a peripheral enkephalinase inhibitor. Unlike other opioid medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect — it reduces the secretion of water and electrolytes into the intestine.
How does racecadotril work?
Racecadotril is an inhibitor of enkephalinase that acts peripherally. Once administered it is metabolized to thiorphan the active ingredient. The active ingredient inhibits the function of a peptidase found on the cell membrane of the epithelial tissues of the small intestines.
What is the difference between Thiorphan and racecadotril?
Thiorphan is the active metabolite of racecadotril, which exerts the bulk of its inhibitory actions on enkephalinases. Racecadotril is used for the treatment of acute diarrhea in children and adults and has better tolerability than loperamide, as it causes less constipation and flatulence.
Is racecadotril an enkephalinase inhibitor?
Racecadotril (ecadotril, anorphan, (S)-aetophan), through its active metabolite thiorphan, is an inhibitor of the neutral endopeptidase known as enkephalinase, thereby increasing exposure to substrates of the enzyme, including enkephalins and atrial natriuretic peptide [1 ].