What is pathophysiology of iron deficiency?
IDA is a hypochromic-microcytic anemia – red blood cells (RBCs) are abnormally small with low levels of hemoglobin (hgb) Despite the cause, IDA occurs when the body’s iron demand exceeds that of it’s supply. Two types: iron store depletion vs. metabolic/functional.
What is the physiological function of iron?
Iron is a mineral that our bodies need for many functions. For example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. It helps our muscles store and use oxygen. Iron is also part of many other proteins and enzymes.
What are the stages of iron deficiency?
Stage 1 – Storage Depletion – Lower than expected blood ferritin levels. Ferritin is the storage form of iron, and low ferritin levels are the first sign that the body’s iron stores are compromised. Stage 2 – Mild Deficiency- During the second stage of iron deficiency, transport iron ( known as transferrin) decreases.
How does iron regulate gene expression?
Iron regulatory proteins (IRPs) regulate the expression of genes involved in iron metabolism by binding to RNA stem-loop structures known as iron responsive elements (IREs) in target mRNAs.
What are the parameters for iron levels?
The serum iron reference ranges are as follows :
- Male: 80-180 mcg/dL or 14-32 μmol/L (SI units)
- Female: 60-160 mcg/dL or 11-29 μmol/L (SI units)
- Newborn: 100-250 mcg/dL.
- Child: 50-120 mcg/dL.
What are sources of iron?
Good sources of iron red meat. beans, such as red kidney beans, edamame beans and chickpeas. nuts. dried fruit – such as dried apricots.
What is RDA of iron?
The Recommended Dietary Allowance (RDA) for all age groups of men and postmenopausal women is 8 mg/day; the RDA for premenopausal women is 18 mg/day. The median dietary intake of iron is approximately 16 to 18 mg/day for men and 12 mg/day for women.