How is HIF 1 regulated?
Under normal oxygen tension, HIF-1α protein expression is negatively regulated by proteasomal degradation and ubiquitination in a pathway involving von Hippel−Lindau protein (pVHL), a tumor suppressor protein and one of the recognized components of an E3 ubiquitin protein ligase27.
What Is HIF in cancer?
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
How is HIF activated?
Insulin likewise activates HIF-1α by activating multiple protein kinases necessary for expression and function [37]. In another study on HIF-1 activation, homozygous deletion of the p53 gene led to HIF-1 activation [38]. Therefore, p53, responsible for promoting ubiquitination of HIF-1α, may be another possible target.
What is the function of fih-1?
The protein dioxygenase FIH-1 is an oxygen-dependent asparaginyl hydroxylase, which was initially reported to regulate the activity of the transcription factor complex hypoxia-inducible factor (HIF) ( Lando et al., 2002a ).
How does factor inhibiting HIF1α (fih-1) function as a tumor suppressor?
Factor inhibiting HIF1α (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1α pathway NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys My NCBISign in to NCBISign Out PMC US National Library of Medicine National Institutes of Health
Does fih-1 bind to VHL?
In addition, we demonstrate that FIH-1 binds to VHL and that VHL also functions as a transcriptional corepressor that inhibits HIF-1α transactivation function by recruiting histone deacetylases.
What does no-downregulation of fih-1 mean?
No-downregulation of FIH-1 was defined as no differences of IHC staining between CRC tissue and its paired normal tissue, or upregulation of FIH-1 in CRC tissue. Immunodeficient mouse xenograft tumor model