Why do we give octreotide in GI bleed?
Octreotide inhibits both acid and pepsin secretion. As a result, it prevents the dissolution of freshly formed clots at the site of bleeding [5].
Does octreotide help with lower GI bleed?
These side-effects were not observed in our patients. A single patient with underlying cardiac disease had sinus bradycardia of unclear etiology. Conclusion: Octreotide is well tolerated in children and is effective in controlling both upper and lower GI bleeding.
Is vasopressin used for GI bleed?
Vasopressin is a potent vasoconstrictor which greatly reduces mesenteric blood flow. In patients with portal hypertension this results in decreased portal venous flow and portal pressure. Because of this property, vasopressin has been used for years in the therapy of variceal haemorrhage.
How does vasopressin decrease bleeding?
Vasopressin regulates plasma volume, blood pressure, and osmolality. It causes vasoconstriction by acting through the vasopressin (V1) receptor and exerts its antidiuretic action through the V2 receptor in the kidney. The major mechanism by which vasopressin reduces blood loss is vasoconstriction.
Why is octreotide used in GI bleed?
Bajaj JS,Sanyal AJ.
How does octreotide help bleeding?
Variceal bleeding:Octreotide decreases the inflow of blood to portal system by constricting the splanchnic arterioles and significantly reduces intravariceal pressure.
How does octreotide stop bleeding?
How does octreotide stop bleeding? With GI bleeders, Octreotide acts as a vasoconstrictor, which causes varices (if the source of the bleed) to shrink down and hopefully stop bleeding. That’s the most common use of octreotide in the hospital setting.
How does octreotide help esophageal varices?
Treatment to prevent bleeding. Treatments to lower blood pressure in the portal vein may reduce the risk of bleeding esophageal varices.