What does an elevated SDMA mean?
An elevated SDMA* concentration is a reflection of impaired glomerular filtration rate (GFR). Both primary kidney disease and secondary kidney insults, such as concurrent disease, can cause an elevation in SDMA concentration.
When should I run SDMA?
Run SDMA every time you run creatinine and BUN SDMA is more reliable than creatinine as an indicator of kidney function because it is not influenced by confounding conditions. SDMA is an earlier indicator of progressive kidney function loss, often increasing before other parameters.
Can dehydration increase SDMA?
Does dehydration impact IDEXX SDMA concentration? If dehydration results in a prerenal azotemia reflecting a reduction in GFR, then SDMA should also increase.
Can SDMA be falsely elevated?
SDMA correlates with strongly with GFR. There are no known interferences that are expected to cause a falsely increased SDMA. SDMA increases only when GFR is reduced. However, if GFR is reduced with prerenal or postrenal azotemia, then SDMA will increase accordingly.
Can UTI cause elevated SDMA?
SDMA is a more sensitive indicator of kidney function than creatinine in AKI as well as CKD and increases earlier. In pets like Reese, an increased SDMA in the face of a urinary tract infection should lead to additional investigation and a consideration for more aggressive treatment for pyelonephritis.
What does SDMA mean in a blood test?
Symmetric dimethylarginine (SDMA) is a new renal biomarker that should be run alongside creatinine, BUN, and a urinalysis to help diagnose kidney disease earlier and with more confidence. The International Renal Interest Society (IRIS) has also added SDMA to their staging guidelines for chronic kidney disease (CKD).
How do I run SDMA on Catalyst one?
How to run SDMA on a Catalyst Dx Chemistry Analyzer
- Enter the sample information on the IDEXX VetLab Station.
- Select the patient and sample type on your Catalyst Dx Chemistry Analyzer.
- Load your sample, chemistry CLIP, and SDMA slide.
- Load the reagent and tap Run on the analyzer.
How sensitive is SDMA?
IDEXX SDMA is a reliable marker for kidney disease, that is both sensitive and specific, increasing on average when there is a 40% reduction in GFR due to cancer or other conditions.
What sample is needed for SDMA test?
The recommended sample volume to run the Catalyst SDMA Test depends on the type of sample you’re using. For whole blood, we recommend 600–800 µL. If you’re testing serum/plasma, we recommend 65 µL, or 300 µL to run SDMA with other tests.
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