What is reduced intensity conditioning?
Reduced intensity conditioning refers to a conditioning regimen that uses less chemotherapy and radiation than the standard regimen, which destroys the patient’s bone marrow cells, (a result known as myeloablation).
What is TBI conditioning regimen?
Total body irradiation (TBI) is widely used in conditioning regimens for patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (HSCT).
What is RIC transplant?
Clearly, AML is a disease of older patients, and over the years, recognition of the need to offer transplantation to older adults and/or patients with comorbid disease has spurred the development of less toxic, more tolerable preparative regimens – the so-called reduced intensity conditioning (RIC) regimens.
What is allo HCT?
Allo HSCT is a procedure in which a portion of a healthy donor’s stem cell or bone marrow is obtained and prepared for intravenous infusion.
What is conditioning therapy?
Conditioning therapies include combinations of chemotherapy, radiotherapy and/or immunotherapy, using different regimens. The aim of conditioning regimens is to reduce relapse and rejection and can be fine-tuned to reduce treatment-related mortality.
What is non myeloablative conditioning?
Non-myeloablative (NMA) conditioning regimens for allogeneic hematopoietic cell transplantation (HCT) are mainly immunosuppressive and less toxic to the recipients’ stem cells. NMA regimens allowed options of HCTs for patients who were traditionally not eligible due to advanced age or comorbidities.
What is the difference between myeloablative and Nonmyeloablative?
Non-myeloablative transplants differ primarily in what happens prior to the transplant. Compared to myeloablative transplants, mini-transplants use much lower and less toxic doses of chemotherapy and radiation, followed by the infusion of donor stem cells.
What is reduced-intensity conditioning?
Reduced-intensity conditioning (RIC) regimens were introduced as a way to exploit the GVL effect of allogeneic transplant while reducing transplant-related mortality, making transplant more available to a patient population in which the median age at diagnosis is 72 years.
What is reduced-intensity conditioning (RIC) for CML?
Reduced-intensity conditioning (RIC) or nonablative transplant approaches have been introduced with the aim of avoiding the toxicities of high-dose preparative regimens while retaining GVL effects. These approaches are of particular relevance for patients with CML because their median age at diagnosis is 67 years.
Is reduced-intensity conditioning a viable treatment option for hematological malignancies in older patients?
Therefore, the older population is generally unsuited to this form of treatment, even though most hematological malignancies are often diagnosed at the age of 70-80 years. The advent of reduced-intensity conditioning (RIC) has provided these patients with a viable treatment option.
What are the most common diseases with reduced intensity regimens?
The most common diseases in which reduced intensity regimens are being explored are AML, non-Hodgkin lymphoma (NHL), and plasma cell disorders (CIBMTR data, Figure 1A ). Reduced-intensity regimens have expanded the applicability of allogeneic transplants to older patients.