What is the role of CD40?
CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.
Where is CD40 found?
CD40 is a 40- to 45-kD type I membrane protein and a member of the TNFR superfamily. The CD40 gene is located in chromosome 20 (q12-q13. 2) and exists as a constitutional trimer complex on the cell surface.
What is the main role of CD40 activation in B cells?
CD40 activation of B cells results in the activation of numerous biochemical pathways, contributing to biological outcomes including enhanced cell survival and proliferation, germinal center formation, memory B cell development, and Ig isotype switching and affinity maturation (2).
What is sea CD40?
SEA CD40 is a non-fucosylated IgG1 monoclonal antibody, targeting CD40 and enhances immune response, being developed by Seagen (formerly Seattle Genetics), as an intravenous and a subcutaneous formulation, for the treatment of solid tumours, including pancreatic cancer, malignant melanoma, non-small cell lung cancer …
What is CD40 ligand deficiency?
BACKGROUND CD40 ligand (CD40L) deficiency is a rare X linked immunodeficiency disorder leading to recurrent bacterial infection, with cryptosporidial enteritis and subsequent hepatic cirrhosis. Bone marrow transplantation offers the only cure.
Is CD40 a receptor?
Cluster of differentiation 40, CD40 (also known TNFRSF5, Tumor necrosis factor receptor superfamily member 5.) is a costimulatory protein and expresses on antigen presenting cells (APC). In human, CD40 is coded by TNFRSF5 gene and has 7 transcripts.
How common is CD40 ligand deficiency?
CD40 ligand deficiency is an uncommon primary immune deficiency with an estimated annual incidence of 1 in 106 (1). CD40 ligand is preferentially expressed on activated CD4+ T cells and binds its cognate receptor, CD40, expressed on B cells, macrophages and antigen presenting cells [1, 2].
What is the CD40LG gene?
Learn more The CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. CD40 ligand attaches like a key in a lock to its receptor protein, CD40, which is located on the surface of immune system cells known as B cells.
What is the CD40/CD40L interaction?
It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. Recent studies have suggested that CD40/CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and the cardiovascular systems.
Is aliquoting necessary for-20oC storage of CD40 ligands?
Aliquoting is unnecessary for -20oC storage. The CD40 ligand (CD40L, TRAP, CD154), a member of the TNF superfamily of ligands, is expressed as either a 33-kd transmembrane homologue or 18-kd soluble form (sCD154). CD40L is primarily expressed on activated CD4+ T cells and on a small proportion of CD8+ T cells and platelets.
Does 16668-1-ap target cd40l/cd154?
16668-1-AP targets CD40L/CD154 in WB, IP, IHC, IF,ELISA applications and shows reactivity with human, mouse samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3.