What is dexrazoxane used for?
Dexrazoxane injection (Totect, Zinecard) is used to prevent or decrease thickening of the heart muscles caused by doxorubicin in women who are taking the medication to treat breast cancer that has spread to other parts of the body.
Is dexrazoxane a chemotherapy?
Dexrazoxane is used to reduce the incidence and severity of heart problems associated with the chemotherapy agent doxorubicin in women being treated for metastatic breast cancer. It is only used for women who have received a high cumulative dose of doxorubicin and who would benefit from continued therapy.
How do you administer dexrazoxane?
Dosage and administration of dexrazoxane Dexrazoxane should be administered as an iv infusion over 1 to 2 hours in a large caliber vein in an extremity/area other than the one affected by the extravasation.
Is dexrazoxane FDA approved?
On September 6, 2007, the U.S. Food and Drug Administration approved Totect 500 mg (dexrazoxane hydrochloride for injection) for the treatment of extravasation resulting from i.v. anthracycline chemotherapy.
When do you take dexrazoxane?
The indication for treatment with dexrazoxane is prevention of chronic cumulative cardiotoxicity caused by doxorubicin or epirubicin use in advanced and/or metastatic adult breast cancer patients who have received a prior cumulative dose of 300 mg/m2 of doxorubicin or 540 mg/m2 of epirubicin and when further …
How long do side effects of cyclophosphamide last?
Possible Side Effects (More Common) Nausea and throwing up (vomiting). These symptoms may happen within a few hours after your treatment and may last up to 72 hours.
How many hours after an epirubicin extravasation is the antidote initiated?
Extravasation Management. Apply ice for 6-12 hours following sodium thiosulfate antidote injection (Merck and Co., Inc., 2005).
How do you make dexrazoxane?
Preparation: Dexrazoxane must be reconstituted with 0.167 Molar (M/6) Sodium Lactate Injection USP to give a concentration of 10 mg dexrazoxane for each mL of sodium lactate. The reconstituted solution should be given by slow I.V. push or rapid drip intravenous infusion from a bag.
What is the Hcpcs code for dexrazoxane Hydrochloride Injection 250mg?
HCPCS Code for Injection, dexrazoxane hydrochloride, per 250 mg J1190.
What are the pharmacokinetics of dexrazoxane?
The pharmacokinetics of dexrazoxane were found to be similar to other reported data in other settings and at lower doses. The rapid appearance of ADR-925 in plasma may make ADR-925 available to be taken up by heart tissue and bind free iron.
How is dexdexrazoxane given?
Dexrazoxane is given as an infusion into a vein. A healthcare provider will give you this injection. Totect is usually started within 6 hours after extravasation, and continued once daily for 3 days.
What is the KOC value of dexrazoxane?
The Koc of dexrazoxane is estimated as 24 (SRC), using a log Kow of 0.025 (1) and a regression-derived equation (2). According to a classification scheme (3), this estimated Koc value suggests that dexrazoxane is expected to have very high mobility in soil.
Is dexrazoxane a Razoxane or chelator?
(+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent. Dexrazoxane is a Cytoprotective Agent. 4- [ (2 S )-2- (3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione Computed by Lexichem TK 2.7.0 (PubChem release 2021.05.07)
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