Does Pseudoxanthoma have Elasticum?
Description. Pseudoxanthoma elasticum (PXE) is a progressive disorder that is characterized by the accumulation of deposits of calcium and other minerals (mineralization) in elastic fibers. Elastic fibers are a component of connective tissue, which provides strength and flexibility to structures throughout the body.
What are Pseudoxanthoma Elasticum symptoms?
PXE may cause the following symptoms: growth of yellowish bumps on the skin of the neck, under the arms, or in the groin area; reduced vision; periodic weakness in the legs (claudication); or bleeding in the gastrointestinal tract, particularly the stomach.
Can Pseudoxanthoma Elasticum cause blindness?
Sometimes, these blood vessels leak and bleed. This bleeding results in the loss of central vision. While people with PXE may lose so much vision that they become legally blind, almost all people with PXE continue to have peripheral vision.
How is Pseudoxanthoma Elasticum treated?
There is no cure for PXE; the main symptomatic treatments are vascular endothelial growth factor inhibitor therapy (for ophthalmic manifestations), lifestyle, lipid-lowering and dietary measures (for reducing vascular risk factors), and vascular surgery (for severe cardiovascular manifestations).
Is Pseudoxanthoma Elasticum an autoimmune disease?
Pseudoxanthoma elasticum (PXE) is a rare, inherited disorder of the connective tissue. Possible association of autoimmune thyroiditis and PXE has been suggested, but reports of other autoimmune diseases complicating PXE are rare.
Is PXE a disability?
Individuals with PXE may require frequent breaks if their work duties require frequent sustained walking or other physical activity. While skin involvement is not generally considered a disability, please refer to our Reconstructive Surgery Bulletin for insurance issues.
Is PXE a rare disease?
Pseudoxanthoma elasticum (PXE) is a rare disorder of degeneration of the elastic fibers with tiny areas of calcification in the skin, back of the eyes (retinae), and blood vessels.