What is KLF4 gene?
KLF4 Gene – Kruppel Like Factor 4 This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin.
What activates KLF4?
Interactions. KLF4 can activate transcription by interacting via it N-terminus with specific transcriptional co-activators, such as p300-CBP coactivator family. Transcriptional repression by KLF4 is carried out by KLF4 competing with an activator for binding to a target DNA sequence (9-12).
Is KLF4 an oncogene?
KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells.
Is KLF4 a stem cell marker?
In recent years, KLF4 has gained notoriety not only due its diverse functions in physiology and diseases but due to its role as one of four key factors required for inducing pluripotent stem cells.
What is the function of KLF4?
Not only does KLF4 play a role in regulating centrosome duplication following DNA damage, but it regulates both centrosome duplication and chromosome number (genetic stability) both in vitro and in vivo (34,35). One of the main roles of KLF4 in the cell is promoting survival by suppressing apoptosis (36–41).
What DNA structure does c-myc a protein bind in DNA?
In the human genome, C-myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes).
Is Klf4 a stem cell marker?
What is the role of KLF4 in transcription?
The participation of KLF4in the mechanism of transactivation of its target genes is greatly regulated. Studies indicate that KLF4 performs key functions in the activation of transcription of many target genes such as KLF4, Nanog, Oct4, p21, p27, Rb, and Sox2 [43].
Is Klf4 expressed during pre-implantation development?
However, there is no significant phenotype during pre-implantation development (Table 38.1), although Klf4is highly expressed in mouse four-cell and morula stage embryos and in human morula stage embryos (Table 38.1; Figure 38.2) (Hamatani et al., 2004; Zeng et al., 2004; Vassena et al., 2011). View chapterPurchase book Read full chapter
What is the role of KLF4 in somatic stem cell differentiation?
KLF4 is a direct target of STAT3 downstream of LIF signaling, and its overexpression causes ES cells to be partially independent of LIF for self-renewal (Hall et al., 2009; Li et al., 2005; Niwa, Ogawa, Shimosato, & Adachi, 2009). From:Current Topics in Developmental Biology, 2016 Related terms: Somatic Cell Stem Cells SOX2 Transcription Factors
Why is Klf4 necessary for the efficient generation of iPS cells?
The fact that Klf4 is necessary for the efficient generation of iPS cells could be explained by its role in the maintenance of ES cells pluripotency. Klf4 has been observed to be upregulated by the leukemia inhibition factor (LIF), which maintains pluripotency in mouse ES cells.