How do you check voriconazole levels?
Draw blood in a plain red-top tube(s). Spin down and send 2 mL of serum frozen in plastic vial. Reference Range: 1.0-5.5 mcg/mL Trough level (i.e., immediately before the next dose) monitoring is recommended.
When do you measure voriconazole trough?
Recently, experts have suggested that voriconazole trough blood levels should be measured after 1 week of therapy for dose adjustment to target values of 2–6 mg/L [7].
What is voriconazole dosing?
Adults weighing less than 40 kilograms (kg)—At first, a loading dose of voriconazole injection is given by your doctor on the first 24 hours of treatment. Then, your doctor may switch you to an oral maintenance dose of 100 or 150 milligrams (mg) taken every 12 hours. Your doctor may adjust your dose as needed.
What is voriconazole 200mg?
Voriconazole is used to treat serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (infections in the skin, stomach, kidney, bladder, or wounds).
What is voriconazole test?
Test Indications: Monitoring trough levels of voriconazole is suggested in individuals with. reduced liver function, individuals with CYP2C19 polymorphisms associated with poor metabolic function, patients taking other medications that affect CYP2C19 activity, and in patients experiencing potential toxicity.
When do you draw Flucytosine levels?
Obtain drug levels after 3-54 days of continuous dosing.
How often should you monitor voriconazole levels?
First level should be drawn at Day 5-7 (steady state) • Follow-up levels may be performed once monthly • Reasons for checking trough levels more frequently: • Changes in voriconazole dosing or route, GVHD with diarrhea, addition or withdrawal of interacting medications, diarrhea, or perceived fungal disease progression …
How is voriconazole administered?
It is recommended that Voriconazole Pfizer is administered at a maximum rate of 3 mg/kg per hour over 1 to 3 hours. Voriconazole Pfizer is also available as 50 mg and 200 mg film-coated tablets and 40 mg/ml powder for oral suspension.
How do you administer voriconazole injection?
Administer VFEND Tablets or Oral Suspension at least one hour before or after a meal. VFEND I.V. for Injection requires reconstitution to 10 mg/mL and subsequent dilution to 5 mg/mL or less prior to administration as an infusion, at a maximum rate of 3 mg/kg per hour over 1 to 3 hours.
How do you administer IV voriconazole?
VFEND I.V. for Injection requires reconstitution to 10 mg/mL and subsequent dilution to 5 mg/mL or less prior to administration as an infusion, at a maximum rate of 3 mg/kg per hour over 1 to 3 hours. Administer diluted VFEND I.V. by intravenous infusion over 1 to 3 hours only.
Is voriconazole toxic?
Toxicity is difficult to determine in immunosuppressed patients because of numerous comorbidities and other toxic treatments. Some retrospective studies have related toxicity to voriconazole blood levels above 5.0 or 5.5 μg/mL [1, 2].
How many voriconazole trough levels are measured per patient?
Measurements of voriconazole trough blood levels. A total of 181 voriconazole trough levels were measured (median number per patient, 4.5; range, 1–9). The median time interval between dose administration and measurement of trough levels was 12 h (range, 11–13 h).
What is the role of dose adjustment in the evaluation of voriconazole?
Because it is difficult to clinically identify individuals with inappropriate exposure, dose adjustment after documentation of low or high voriconazole levels is critical if infection is not responding to treatment or if toxicity is suspected.
What is the safest level of voriconazole?
Safety of voriconazole therapy. Voriconazole trough levels were ⩽5.5 mg/L in 36 patients (69%) and >5.5 mg/L in 16 patients (31%) (table 4). The majority of patients with voriconazole levels >5.5 mg/L received voriconazole intravenously, and a significant proportion of these patients received omeprazole comedication.
Is voriconazole therapeutic drug monitoring effective in the treatment of invasive mycoses?
Conclusions. Voriconazole therapeutic drug monitoring improves the efficacy and safety of therapy in severely ill patients with invasive mycoses.