How does the drug aminophylline work?
Aminophylline is a bronchodilator. Aminophylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.
What are the negative effects of aminophylline?
Aminophylline side effects fast or irregular heartbeats; a seizure; high blood sugar–increased thirst, increased urination, dry mouth, fruity breath odor; or. low potassium level–leg cramps, constipation, irregular heartbeats, fluttering in your chest, numbness or tingling, muscle weakness or limp feeling.
What are the indications for aminophylline?
Aminophylline Injection is indicated for relief of bronchospasm associated with asthma and in chronic obstructive pulmonary disease.
Why is aminophylline given slowly?
Intravenous Aminophylline must be administered very slowly to prevent dangerous central nervous system and cardiovascular side-effects due to direct stimulating effect of Aminophylline.
Why aminophylline is not recommended?
In the adult literature, a Cochrane review from 2012 recommends that aminophylline should not be considered for use in acute asthma due to serious side-effects and limited efficacy [17].
Is aminophylline still used?
There is presently no evidence to support the use of aminophylline in addition to standard therapy for acute asthma in adults.
Who should not take aminophylline?
Infection, severe (e.g., sepsis) or. Kidney disease in infants younger than 3 months of age or. Liver disease (e.g., cirrhosis, hepatitis) or. Pulmonary edema (lung condition) or.
What medications contain aminophylline?
Product(s) containing aminophylline:
- aminophylline systemic. Brand names: Phyllocontin, Truphylline.
- aminophylline/amobarbital/ephedrine systemic.
- aminophylline/ephedrine/guaifenesin/phenobarbital systemic.
- aminophylline/ephedrine/phenobarbital/potassium iodide systemic.
- aminophylline/guaifenesin systemic.
How do you take aminophylline injection?
Aminophylline Injection is administered by slow intravenous injection or diluted and administered by intravenous infusion. The solution contains no bacteriostat or antimicrobial agent and is intended for use only as a single-dose injection. When smaller doses are required the unused portion should be discarded.
Can a pregnant woman take aminophylline?
Aminophylline should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Aminophylline should be given to a pregnant woman only if clearly needed.
Can a child take aminophylline?
Children and teenagers 1 to 15 years of age weighing less than 45 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. At first, the dose is 15.2 to 17.7 milligrams (mg) per kg of body weight per day, divided and given every 4 to 6 hours. Your doctor may adjust your dose as needed.
Is caffeine a xanthine?
The xanthine derivatives are agents that resemble natural occurring xanthines such as caffeine, theobromine and methylxanthines. These are plant alkaloids and components of coffee, tea and chocolate.
What is aminophylline?
Aminophylline is a complex of theophylline and ethylenediamine. Theophylline crosses the placenta. Refer to Theophylline monograph for additional information. What is this drug used for? • It is used to treat breathing problems.
Does aminophylline have any effect on the heart?
Concluding, intravenous aminophylline may lead to acute cardiovascular changes. Thus, if aminophylline is used for treatment of MAS, its possible cardiovascular effects should be considered, particularly in patients with cardiovascular instability.
How long does aminophylline stay in your system?
Theophylline clearance rates and half-life values were measured in 15 infants aged three to 23 months, after infusion of aminophylline by the intravenous route for at least 24 hours. The mean half-life was 4.4 +/- 2.2 hours.
Can aminophylline be used to treat shortness of breath?
Uses of Aminophylline: It is used to treat breathing problems. This medicine is not to be used to treat intense flare-ups of shortness of breath. Use a rescue inhaler. Talk with the doctor.