What is the medication papaverine used for?
Descriptions. Papaverine belongs to the group of medicines called vasodilators. Vasodilators cause blood vessels to expand, thereby increasing blood flow. Papaverine is used to produce erections in some men with erectile dysfunction.
What drug class is papaverine?
It belongs to the benzylisoquinoline group of alkaloids. It does not contain a phenanthrene group as do morphine and codeine. Papaverine Hydrochloride, USP, is 6,7-dimethoxy-1- veratrylisoquinoline hydrochloride and contains, on the dried basis, not less than 98.5% of C20H21NO4•HCI. The molecular weight is 375.85.
What is the action of papaverine?
The main actions of papaverine are exerted on cardiac and smooth muscle. Like quinidine, papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists.
Is papaverine still used?
It is used in the treatment of acute mesenteric ischemia. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic morphine-like compounds….Papaverine.
| Clinical data | |
|---|---|
| Pronunciation | /pəˈpævəriːn/ |
| Trade names | Pavabid, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682707 |
How is papaverine given?
Papaverine is injected into a muscle, or into a vein through an IV. A healthcare provider will give you this injection. When injected into a vein, papaverine must be given slowly (over 1 or 2 minutes) to prevent vein irritation or other side effects.
What type of antagonist is papaverine?
Papaverine is an inhibitor of PDE enzyme leading to increase cGMP in penile tissue. The major disadvantage of papaverine is corporal fibrozis thought to be a result of low acidity. Phentolamine is an α-receptor antagonist that increases blood flow. Systemic hypotension and tachycardia are its major adverse effects.
Where is papaverine found?
Papaverine is an alkaloid that is present in opium and is also used clinically as an antispasmodic and vasodilator. Papaverine is used to treat many conditions that cause spasm of smooth muscle, including heart attacks, chest pains, circulation problems, or disorders of the stomach or gallbladder.
How is papaverine made?
In analogy to that synthesis (in which two moles of water were removed in the final cyclization step), one mole water and one mole methanol are removed by a cyclization agent, and papaverine is formed.
Where is papaverine injected?
Using a sterile needle, inject the medicine slowly and directly into the base of the penis as instructed by your doctor. Papaverine should not be injected just under the skin. The injection is usually not painful, although you may feel some tingling in the tip of your penis.
Does papaverine increase blood pressure?
Papaverine is a vasodilator that relaxes smooth muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Papaverine is used to treat many conditions that cause spasm of smooth muscle.
How do you take papaverine?
Papaverine comes as a tablet and extended-release (long-acting) capsule to take by mouth. The tablet usually is taken three to five times a day at evenly spaced intervals. The extended-release capsule usually is taken every 8-12 hours. Do not crush, chew, or divide the extended-release capsules.
What are side effects of papaverine?
Papaverine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- flushing (feeling of warmth)
- sweating.
- headache.
- tiredness.
- dizziness.
- skin rash.
- upset stomach.
- loss of appetite.
What is papaverine used to treat?
In the U.S. Papaverine belongs to the group of medicines called vasodilators. Vasodilators cause blood vessels to expand, thereby increasing blood flow. Papaverine is used to treat problems resulting from poor blood circulation. Papaverine is available only with your doctor’s prescription.
What is the chemical name of papaverine hydrochloride?
Papaverine hydrochloride, C 20H 21NO 4•HCl, is a white, crystalline powder, odorless, with a slight bitter taste and is soluble in water. Each capsule contains: papaverine hydrochloride USP 150 mg. Chemically, it is Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride. It has a molecular weight of 375.85.
What is the history of papaverine?
Papaverine occurs naturally in opium. Papaverine was discovered in 1848 by Georg Merck (1825–1873). Merck was a student of the German chemists Justus von Liebig and August Hofmann, and he was the son of Emanuel Merck (1794–1855), founder of the Merck corporation, a major German chemical and pharmaceutical company.
What are the side effects of papaverine?
Papaverine side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have:
