What is notochordal cell tumor?
A Benign Notochordal Cell Tumour, or a “BNCT”, is a non-cancerous growth that arises in the bones of the spine. The same growth has been called different names over the years, including notochordal rest or vertebral notochordal rest, but the official terminology is now Benign Notochordal Cell Tumour.
What is a notochordal remnant?
Notochordal remnants are occasionally found in the fetal and adult vertebrae on autopsy. Giant vertebral notochordal rest and notochordal hamartoma are terms that have been used to describe what is now collectively referred to as benign notochordal cell tumors.
Can chordoma be benign?
because they are relatively slow growing and they most often recur locally rather than spreading throughout the body. Because chordomas are low-grade, sometimes they are mistakenly called benign. Benign tumors do not invade other tissue, do not metastasize, and usually do not return after being removed.
What happens notochord?
The notochord functions as the primary axial skeleton of chordates during embryogenesis. In most vertebrates, the notochord is eventually replaced by ossified vertebrae, but it persists throughout the life of invertebrate chordates (Stemple, 2005; Trapani, Bonaldo, & Corallo, 2017).
What are the notochordal remnants in adults?
The notochord is cylindrical and is replaced by sclerotomes that produce cartilage, and subsequently bone. The nucleus pulposus of the intervertebral discs represents residual notochord. In non-human species, cells of the notochord alongside the mucoid nucleus pulposus continue to exist after adulthood.
Can you feel a cervical spine tumor?
Spinal tumor pain may feel like an achiness or discomfort deep within the back, rather than feeling painful on the surface or skin. Sharp or shock-like pain.
What does a chordoma tumor feel like?
These symptoms can include tingling, numbness, weakness, lack of bladder or bowel control, sexual dysfunction, vision problems, endocrine problems and swallowing difficulties. If the chordoma has grown very large, you may be able to feel a lump.
What is notochordal plate?
Developmental Ontology. The notochordal plate develops from the notochordal process, which is morphologically modified from a hollow tube shape to a flattened plate shape. The ventral floor of the notochordal process fuses with the endodermal layer beneath it and thus assumes a flat shape.
Is notochord and backbone same?
A notochord is a primitive beginning to the backbone. It appears in embryos as a small flexible rod made from cells from the mesoderm, which is one of the three layers of cells of embryos. Notochords are only found in the phylum chordata, a group of animals that includes humans.
What does nucleus pulposus mean?
Nucleus pulposus is the inner core of the vertebral disc. The core is composed of a jelly-like material that consists of mainly water, as well as a loose network of collagen fibers. The elastic inner structure allows the vertebral disc to withstand forces of compression and torsion.
What is notochord in human?
notochord, flexible rodlike structure of mesodermal cells that is the principal longitudinal structural element of chordates and of the early embryo of vertebrates, in both of which it plays an organizational role in nervous system development. In later vertebrate development, it becomes part of the vertebral column.