What does Immunofixation electrophoresis test for?
A serum immunofixation test measures specific proteins in your blood. It helps to identify certain illnesses that are otherwise hard to detect, such as multiple myeloma, a blood cancer. The test is also known as IFE, immunofixation electrophoresis, or protein electrophoresis.
What is protein electrophoresis blood test for?
The test separates proteins in the blood based on their electrical charge. The protein electrophoresis test is often used to find abnormal substances called M proteins. The presence of M proteins can be a sign of a type of cancer called myeloma, or multiple myeloma.
What does an abnormal immunofixation mean?
An abnormal result may be due to: Amyloidosis (buildup of abnormal proteins in tissues and organs) Leukemia or Waldenström macroglobulinemia (types of white blood cell cancers) Lymphoma (cancer of the lymph tissue) Monoclonal gammopathy of unknown significance (MGUS)
What diseases does Spep test for?
SPEP is used to help diagnose and monitor a variety of different diseases or disorders that have abnormal proteins or protein levels….Some of the conditions that could be causing these symptoms are:
- cancer.
- thyroid problems.
- diabetes.
- anemia.
- liver diseases.
- malnutrition.
- certain autoimmune diseases.
- multiple sclerosis.
What causes Immunofixation electrophoresis?
Urine protein electrophoresis may be ordered when you have abnormally high levels of protein in your urine. Immunofixation electrophoresis or immunosubtraction electrophoresis may be ordered when an abnormal band suggestive of a monoclonal immunoglobulin is detected on either a serum or a urine electrophoresis.
How is immunofixation performed?
Immunofixation consists of an electrophoresis phase and a fixation phase. In the former, the serum is applied to an agarose gel, and the negatively charged serum proteins move toward the cathode under the influence of an electric current. The speed of movement is dictated by their charge.
Should I be worried about high protein in blood?
High blood protein is not a specific disease or condition in itself, but it might indicate you have a disease. High blood protein rarely causes signs or symptoms on its own. But sometimes it is uncovered while you’re having blood tests done as part of an evaluation for some other problem or symptom.
What causes high protein electrophoresis?
In general, alpha and gamma globulin protein levels increase when there is inflammation in the body. Lipoprotein electrophoresis determines the amount of proteins made up of protein and fat, called lipoproteins (such as LDL cholesterol).
What does a high SPEP mean?
Serum protein electrophoresis is generally considered in any patient with an elevated total protein, especially those with elevated globulin level relative to albumin, or any signs and symptoms suggestive of an underlying plasma cell disorder such as multiple myeloma, Waldenstrom’s macroglobulinemia, or primary …
What is an SPEP panel?
The serum protein electrophoresis (SPEP) test measures specific proteins in the blood to help identify some diseases. Proteins are substances made up of smaller building blocks called amino acids. Proteins carry a positive or a negative electrical charge, and they move in fluid when placed in an electrical field.
What is the difference between immunofixation and electrophoresis?
Urine protein electrophoresis (UPEP) is used to identify the presence of the Bence Jones protein in urine. Immunofixation is used to identify the subtype of protein (ie, IgA lambda).
When should I buy immunofixation?
Immunofixation of the urine and serum should be included in a battery of tests after 2-3 months following diagnosis of smoldering myeloma, then every 4-6 months for 1 year, and, finally, every 6-12 months if the results are stable.
Qu’est-ce que l’électtrophorèse des protéines?
L’ électrophorèse des protéines est un examen permettant d’analyser les protéines présentes dans le sang (ou sérum) ou les urines. Réalisé en routine, simple et peu coûteux, il permet le diagnostic et le suivi de nombreuses maladies. Électrophorèse des protéines : de quoi s’agit-il?
Qu’est-ce que l’électrophorèse des protéines sériques?
L’électrophorèse des protéines sériques est un examen simple, réalisé en routine qui permet de dépister et participe au suivi de nombreuses pathologies… syndromes inflammatoires, certains cancers, désordres physiologiques ou nutritionnels.
Qu’est-ce que les bandes oligoclonales?
Les bandes oligoclonales (BOC) sont des bandes d’ immunoglobulines qui sont observées lorsque le sérum sanguin ou le liquide cérébrospinal (LCS) d’un patient est analysé. Ils sont utilisés dans le diagnostic de diverses maladies neurologiques ou sanguines, en particulier dans la sclérose en plaques . Deux méthodes d’analyse sont possibles :
Comment interpréter les résultats de l’électrophorèse?
Les normes diffèrent selon les laboratoires : les résultats doivent être interprétés par un médecin, en fonction du contexte clinique. L’électrophorèse est utilisée pour mettre en évidence des protéines anormales et identifier des groupes de protéines augmentées ou diminuées dans le sérum ou les urines.