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Which medications prolong QT?

Which medications prolong QT?

Sotalol and amiodarone, class III antiarrhythmics, are known to prolong the QT interval by blocking the IKr.

What is drug induced QT prolongation?

Drug-induced QT prolongation is defined as a QTc of 500 ms or greater or an increase of 60 ms or greater in the QT interval compared with the premedication baseline interval. Attempts should be made to correct any modifiable risk factor.

Do beta blockers prolong QT?

Conclusion: Beta-blockers have heart-rate-dependent effects on the QT and QTc intervals in LQTS. They appear to increase the QT and QTc intervals at slower heart rates and shorten them at faster heart rates during exercise.

Does Zofran prolong QT interval?

GlaxoSmithKline (GSK), the manufacturer of Zofran, was required by FDA to conduct a thorough QT study to assess the potential for the drug to prolong the QT interval. Preliminary review of the study results shows that QT prolongation occurs in a dose-dependent manner.

Which antidepressants cause QT prolongation?

TCAs and SNRIs have also been shown to prolong the QT interval to varying degrees. Certain TCAs (eg, amitriptyline, maprotiline) may lead to QT prolongation, although others do not (eg, clomipramine). The risk of QT prolongation is similarly low for the SNRIs, including duloxetine and desvenlafaxine.

Does metoprolol prolong QT interval?

Conclusions/interpretation: This study is the first to address the QTc interval and QTc dispersion in Type 1 diabetic patients treated with metoprolol. Beta blocker treatment caused a decrease in QTc interval but no change in QTc dispersion.

Does propranolol prolong QT?

Conclusions: Propranolol has a significantly better QTc shortening effect compared to metoprolol and nadolol, especially in patients with prolonged QTc. Propranolol and nadolol are equally effective, whereas symptomatic patients started on metoprolol are at a significantly higher risk for BCEs.

What medications should be avoided with long QT syndrome?

Table 1

Drugs to be avoided in patients with c-long QT syndrome
α1-blocker Alfuzosin
Bronchodilator/decongestant Albuterol, Salmeterol, Metaproterenol, Terbutaline, Metaproterenol, Levalbuterol, Ephedrine, Phenylpropanolamine, Pseudoephedrine
Cholinesterase inhibitor Galantamine
CNS stimulant Amphetamine

Do SSRIs prolong QT interval?

In addition, doses of escitalopram should not exceed 20 mg daily. The rationale cited: higher doses of the SSRIs may prolong the QT interval with no additional therapeutic benefit.

Does Zofran prolong QTc?

Just like many other medications, ondansetron can prolong the QTc interval on an electrocardiogram. In fact, the FDA released a Drug Safety Communication in 2012 recommending against IV doses > 16 mg to help limit the risk.

Do beta-blockers prolong QT?

Does nadolol prolong QT?

As previously mentioned, the protective effect of beta-blockers is related to their adrenergic blockade, which diminishes the risk of cardiac arrhythmias. They may also reduce the QT interval in some patients. Beta-blockers used in patients with LQTS include the following: Nadolol (preferred)

What medications increase QT interval?

Alfuzosin ( Uroxatral ®)

  • Amoxapine
  • Apomorphine ( Apokyn ®)
  • Arformoterol ( Brovana ®)
  • Bitter orange
  • Chloroquine ( Aralen ®)
  • Certain anesthetics
  • Certain antibiotics,including:

    • What drugs increase QT interval?

    – Azithromycin – Clarithromycin – Erythromycin When taken independently, erythromycin has been shown to cause both QT prolongation and TdP. Erythromycin works inhibiting the CYP3A protein.

    Which medications cause prolonged QT?

    age over 65 years;

  • female sex (longer QTc interval than men and twice the risk of drug-induced TdP);
  • myocardial hypertrophy (e.g.,in arterial hypertension);
  • congenital QT syndrome;
  • bradycardia (leads per seto QTc prolongation; sinus bradycardia; 2nd- and 3rd-degree atrioventricular block);
  • electrolyte disturbances (hypokalemia,hypomagnesemia);

    • What drugs cause prolonged QT?

    Pharmacological agents are the most common cause of QT prolongation given the broad range of medications that may induce it. As well, torsade, which is drug-induced, is reversible by the discontinuation of the offending drug. QT-Prolonging Medications Antipsychotics:Haloperidol, ziprasidone, quetiapine, thioridazine, olanzapine, risperidone

    By Naveed Callahan

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