Category: Contributing

Can lichen planus be caused by diabetes?

Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM).

Can smoking cause lichen sclerosus?

Lichen sclerosus in men is associated with elevated body mass index, diabetes mellitus, coronary artery disease and smoking.

What is lichen planus oral?

Lichen planus is a common disease that causes inflammation (swelling and irritation) on your skin or inside your mouth. On your skin, lichen planus causes a rash that is usually itchy. Inside your mouth, it may cause burning or soreness.

Does diabetes affect lichen sclerosus?

Abstract. A review of 76 patients with lichen sclerosus et atrophicus reveals a number of cases in which this disorder is associated with glucose intolerance or diabetes mellitus.

Can metformin cause lichen planus?

Case reports of possible reactions to metformin include erythema multiforme, lichen planus, rosacea, and pseudoporphyria [3–6]. The second most common drug-induced cutaneous reactions are fixed-drug eruptions (FDEs) [7].

What causes lichen sclerosus to flare up?

Irritants such as soap, detergents, shower gels and bubble baths can aggravate lichen sclerosus, so using these irritants should be avoided. Friction or damage to the skin can make it worse so overzealous washing and drying of the vaginal or anal area should be avoided.

What is the difference between lichen sclerosus and lichen planus?

The main difference between the two conditions is that LP has a propensity to involve the mucous membranes including the mouth and vagina which are rarely affected in LS. First-line treatment for LS is a super-potent topical corticosteroid ointment which has a high response rate.

Can metformin cause a rash?

INTRODUCTION. Metformin, a widely used antidiabetic and antiobesity drug, exerts multiple effects on the skin, and could potentially induce a variety of dermatoses. Among others, the most commonly described drug-induced skin reactions include rash, urticaria, and lichenoid eruption.

Which people have lichen sclerosus with diabetes?

Lichen sclerosus is found among people with Diabetes, especially for people who are female, 60+ old. The study analyzes which people have Lichen sclerosus with Diabetes.

How common is lichen planus among patients with diabetes mellitus?

Ten studies assessed the prevalence of lichen planus among patients with diabetes mellitus which showed a prevalence of lichen planus ranging from 0.5% to 6.1% with a relative risk of 1.4. Conclusions: Contradictory results were found when analyzing the relationship between lichen planus and diabetes mellitus.

What is lichen sclerosus and how does it affect the body?

Immune system disorder – the body’s own immune system mistakenly attacks the skin. Patients with lichen sclerosus are at greater risk of developing other autoimmune diseases including thyroid disease, vitiligo (patches of discolored skin), alopecia areata (patchy hair loss) and anemia (low red blood cell count)

What is the prevalence of lichen sclerosus?

It occurs more commonly in postmenopausal women, but premenopausal women, men and children may be affected. Lichen sclerosus can develop on any skin surface, but it usually occurs in the genital and anal regions. 85 to 98% of cases are found near the clitoris, on the labia and in the anal region of women.

Why does Benadryl help my back pain?

Antihistamines inhibit action of histamine by preventing it from attaching to histamine receptors. These pain medications are widely used for the treatment of acid reflux and stomach ulcers and are commonly taken in conjunction with steroidal medications as part of a treatment plan for lower back pain.

Can Benadryl be used for pain?

Some topical, over-the-counter Benadryl products are approved for treating pain and itchy skin caused by insect bites and stings. These products include: Benadryl Itch Stopping Cream.

Does Benadryl help with inflammatory?

Antihistamines have recently been shown to have anti-inflammatory properties that are more extensive than simply the blocking of histamine receptors.

Can Benadryl cause nerve pain?

Nervous system Dystonic reactions have been reported after single doses of diphenhydramine. Pseudoephedrine produces nervous system stimulation, resulting in tremor, anxiety, and nervousness.

Can antihistamines help muscle pain?

A new study in the Journal of Applied Physiology, by Matthew Ely and his colleagues at the University of Oregon, tests the idea that taking a single dose of antihistamine medication can protect you from delayed onset muscle soreness (DOMS) after a hard workout.

What does Benadryl help with?

Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing. It is also used to prevent and treat nausea, vomiting and dizziness caused by motion sickness.

Is Benadryl a nerve pill?

Benadryl is not an anxiety medication. It’s an over-the-counter (OTC) antihistamine. Its primary purpose is to provide temporary relief from hay fever and upper respiratory allergy symptoms.

Does Benadryl help with anxiety?

Benadryl isn’t an effective treatment for anxiety. Since Benadryl can make you feel sleepy, some people may feel that it causes them to relax. However, this effect often goes away after using the product for a few days. Is Benadryl an NSAID? No, Benadryl isn’t an NSAID (nonsteroidal anti-inflammatory drug). Benadryl is an antihistamine.

Does Benadryl have any side effects?

These latter effects are responsible for its sedative effects and side effects such as dry mouth. Benadryl belongs to the class of medicines known as first-generation antihistamines. Benadryl is an antihistamine of the ethanolamine class. 2. Upsides

What is Benadryl used for?

Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and to relieve some symptoms of Parkinson’s disease. Sedation is a common side effect. 5. Tips. Benadryl may be taken with or without food. Take exactly as directed. Do not take more than is recommended.

What pain medications are used to treat lower back pain?

These pain medications are widely used for the treatment of acid reflux and stomach ulcers and are commonly taken in conjunction with steroidal medications as part of a treatment plan for lower back pain. Antihistamines are available in tablet, capsule and liquid forms.

How do I reset my Aprilaire humidifier control?

Purchase genuine Aprilaire water panels. If you replace the Water Panel with an automatic control, you should turn the control knob to the “Test/Reset” position until the “Change Water Panel” light blinks to reset the timer.

How do I control my Aprilaire humidifier?

Turn the humidifier control dial setting to the “Off” position. Then, slowly turn the dial clockwise until you hear the solenoid valve on the humidifier “click on.” Next, slowly turn the dial counter clockwise until you hear the solenoid valve “click off”. At this point, make note of the dial setting.

What should my Aprilaire humidifier be set at?

Relative Humidity Guide Aprilaire, like any other humidifier manufacturer, designs their humidifiers to maintain an indoor relative humidity of 35% at an indoor temperature of 70F, anytime the outdoor temperature is 20F or above.

When should I change my AprilAire water panel?

annually
Water panels are the backbone of your AprilAire Humidifier and they must be replaced annually.

What should my AprilAire be set at in the winter?

What is the proper relative humidity to have in my home during the winter? Aprilaire like any other humidifier manufacturer designs our humidifiers to maintain an indoor relative humidity of 35% at an indoor temperature of 70F, anytime the outdoor temperature is 20F or above.

What should my AprilAire humidifier be set at in winter?

For outdoor temperatures around 10 degrees, set the humidistat to 30 percent. At an outdoor temperature around 20 degrees, a 35 percent humidistat setting is appropriate. For an outdoor temperature near 30 degrees, set your humidistat at 40 percent.

What setting should my AprilAire humidifier be on in the winter?

What should my Aprilaire humidifier be set at in winter?

Should aprilaire be turned off in summer?

Central humidifiers can be very beneficial during the heating season, but it is critical to turn them off once the weather warms up and you start using your AC unit again.

What setting should my Aprilaire humidifier be on in the winter?

How long does an AprilAire water panel last?

The water panels were designed to be used for the season of the humidifier. The water panel in the 400 and 400M models needs to be replaced every 3 months. Every season, the 500, 500M, 600, 600M, 700 and 700M require replacement.

What is the most invasive fish in Florida?

Blue Tilapia They had escaped into the wild by 1961, and were already present on Sanibel when SCCF began sampling freshwater fish in 2003. Blue tilapia are now the most wide-ranging invasive fish in Florida, making themselves at home throughout the state as far north as Gainesville.

What are 4 invasive species of fish in Florida?

Fishing For Invasive Fish In Florida- Species Guide & Tips

• Oscar (Astronotus ocellatus)
• Blue Tilapia (Oreochromis aureus)
• Spotted Tilapia (Tilapia mariae)
• Mayan Cichlid (Cichlasoma urophthalmus)
• Midas Cichlid (Amphilophus citrinellus)
• Jaguar Guapote (Parachromis managuensis)
• Black Acara (Cichlasoma bimaculatum)

What freshwater fish are invasive in Florida?

The Burmese python, green iguana and lionfish are, by now, well-known invasive species that have established a dangerous foothold in Florida. But a fearsome new invasive predator has emerged in the state: the arapaima, a monster fish that can grow up to 10 feet long and weigh hundreds of pounds.

How many invasive fish are in Florida?

More than 145 non-native freshwater fish species have been recorded from Florida since the 1880s. These range from species observed only once to species with established permanent populations in several locations across the state.

Are alligator gar invasive in Florida?

Evaluating Invasive Risk of Alligator Gar (Atractosteus spatula) in Aquaculture in Florida. Alligator Gar, Atractosteus spatula, is imperiled across much of its native habitat; occurring in just a small portion of the Florida panhandle (Figure 2; Buckmeier 2008).

How much does Florida pay for invasive species?

resources in the U.S. is estimated at $137 billion annually. Florida has spent over $300 million to control a single invasive species, the citrus canker. estimated at $179 million.

What should you do if you find an invasive species in Florida?

You can call the FWC’s Exotic Species Hotline at 888-Ive-Got1 (483-4681) to report nonnative animals. We ask the public to call the Hotline to report high priority species, which include all nonnative snakes, monitor lizards, and tegus.

Can you catch invasive species in Florida?

Rules for Catching Invasive Fish in Florida In general, there’s no season or bag limit for non-native or invasive fish in Florida. You can head out and catch as many as you like, whenever you want. More than that, it’s actually illegal to release the fish alive.

What is Florida doing about invasive species?

The Nonnative Fish and Wildlife Program aims to minimize the adverse impacts of nonnative species in Florida through prevention, early detection, rapid response, control and management, and education and outreach.

Can alligator gar bite you?

Danger to Humans Due to its large size and sharp teeth, the alligator gar is capable of delivering a serious bite wound to fisherman or swimmers. However, there is no documentation of attacks on man by alligator gars. The eggs are poisonous, causing illness if consumed by humans.

Why is it called Order 66?

Order 66 may refer to: Order 66 (Star Wars), a fictional pre-arranged military command given during the end of the Clone Wars in the fictional Star Wars universe depicted in the movie Star Wars Episode III: Revenge of the Sith. Order 66/2523, a 1980 anti-communist directive of the Thai government.

What does grievous say after hello there?

Obi-Wan Kenobi: Hello there. General Grievous: General Kenobi. You are a bold one. Kill him!

What was Order 66?

Order 66, also known as Clone Protocol 66, was a top-secret order identifying all Jedi as traitors to the Galactic Republic and, therefore, subject to summary execution by the Grand Army of the Republic.

Who called Order 66?

Darth Sidious/Emperor Palpatine
Order 66 is arguably one of the most important events in the entire Star Wars galaxy. Also known as the Jedi Purge, few Star Wars fans can forget the moment they heard Darth Sidious/Emperor Palpatine utter the ominous words, “Execute Order 66”.

How many times did Obi-Wan Kenobi say hello there?

How many times did Kenobi say hello there? Obi-Wan saying “Hello there” 67 million times | FlowingData.

What does Order 66 mean on YouTube?

Amateur bodybuilder Jason Genova, who frequently incorporates Star Wars references throughout his YouTube videos, also uses Order 66 to urge his followers to attack the social media of someone he doesn’t like. Once his Order 66 has been placed, his many fans will make unpleasant comments about, even threats to,…

What does execute Order 66 mean in Star Wars?

“Execute Order 66” is a line said by Chancellor Palpatine in _Star Wars Episode III: Revenge of the Sith that sparked numerous image macros in the years following its release and resurfaces amidst the Star Wars Episode III meme revival in early 2017. Origin.

What was Order 66 in WW2?

order 66. Hitler’s Commando Order (Kommandobefehl in German) that was secretly distributed to high command, ordering that all irregulars (ie. commandos) captured be handed over to the Sicherheitsdienst (SD: intelligence arm of the SS) for interrogation and execution.

What is Order 66 2523?

Order 66 (podcast), a podcast hosted by David Villegas and Chris Witt Order 66/2523, a 1980 anti-communist directive of the Thai government Standing Order 66, a 1713 British Parliamentary procedure.

https://www.youtube.com/watch?v=W5ZgKFje5T4

What routes does the a330 fly?

Where are Delta’s A330neos to fly?

• JFK to Tel Aviv.
• Seattle-Tokyo Haneda.
• JFK-Amsterdam.
• Seattle-Amsterdam.
• Seattle-Seoul Incheon.
• JFK-Rome Fiumicino.
• JFK-Paris CDG.
• Honolulu-Seattle.

How many aircraft does Oman Air have?

Oman Air Fleet Details and History

Oman Air
Headquarters	Muscat Seeb International (MCT / OOMS)
Fleet Size	50 Aircraft (+ 4 On Order/Planned)
Average Fleet Age 1	6.7 Years
Official Site	omanair.com

Is Oman Air operating in Saudi Arabia?

Oman Air, the national carrier of the Sultanate of Oman, will resume flights to Riyadh KSA on 1st April 2021, operating 4 flights per week. Flights to Dammam KSA resumed on 28 March 2021, operating 4 flights per week.

Which airline has the most A340?

Today, the Airbus A340 has fallen out of favour with most of its original operators, with the notable exception of Lufthansa, and been replaced by more efficient Airbus A350 and Boeing 787 twinjets….The A340 at 30. Which airlines still fly the original Airbus quad jet?

Variant	No. in Service	Operators
A340-200	1	Conviasa

How many countries does Oman Air operate?

27 countries
Destinations. As of July 2020, Oman Air operates a network of 50 destinations in 27 countries out of its primary hub at Muscat.

Is Oman Air part of oneworld?

Oman Air is in the process of becoming a member of the Oneworld alliance with hopes of reaching that goal by the end of 2022. “We are in discussions with Oneworld and (Oneworld member) Qatar Airways has invited us to join the alliance,” Oman Air CEO Abdulaziz Al Raisi told Aviation Daily recently….

Is there a spray that makes your hair smell good?

Byredo Mojave Ghost Hair Perfume This floral woody perfume has a seductive quality and the scent stays put. Just a single spritz or two will last all day.

Can I spray fragrance mist in my hair?

Spraying your favorite perfume on your hair might help short term, but it can damage hair in the long term by drying it out. For a quick fix, try a formula made for hair, such as a hair mist, dry shampoo, or hair serum. In the end, how you treat your hair is up to you.

Is hair mist better than perfume?

Hair mist is a body product that tastes the same or similar to the same perfume and is mainly used to spray on the hair. Because perfume directly spray hair will cause damage to the hair, and hair mist will not, some have the effect of replenishing nutrition to the hair and so on.

What do hairdressers use to make hair smell good?

HAIR PERFUME. Hair perfumes are great as they effectively remove all chemical smells from your hair, make your hair smell great and adds shine. Hair perfumes are not as damaging as actual perfume for your skin as these products do not contain alcohol. Direct contact with alcohol on hair dries out the hair follicle.

How do you get your hair to smell like a salon?

“The trick to getting your hair to smell like your favorite shampoo? Use the conditioner and styling products from the same line, with the same scent. This seals in the fragrance until the next washing. Another option is hair perfume—many brands have created these using their signature fragrance.

What is hair mist spray?

Hair mist is a fragrance that’s designed to be worn on your hair, instead of your skin. It avoids perfume ingredients that can make your hair dry or frizzy. Many hair mists are multitaskers, providing scent as well as styling. And they tend to be a little cheaper than eau de toilette.

How can I make my straight hair smell good?

Baking soda, also known as sodium bicarbonate, has absorbing properties that make it a fantastic odor-neutralizing agent. When used at the right concentration, it neutralizes most unpleasant smells almost immediately. This makes it a great way to get rid of your burnt hair smell.

What happens when you put perfume in your hair?

But although we all like our hair to smell great, you should never spray regular perfume directly on your hair. This is because perfume contains alcohol, which is incredibly drying for hair and can leave it brittle, haystack-like and more likely to suffer breakage.

Does hair fragrance damage hair?

In general, hair perfume will not damage your hair when applied in moderation and in the right manner. Hair perfumes are largely water-based with a tinge of ethyl alcohol which prevents it from drying the scalp, unlike regular alcohol-based perfumes that are formulated for the skin.

Is Chanel hair mist good?

Chanel hair mists are the best under the radar beauty buy. They’re affordable luxury when you compare them to other fragrant hair mists. They smell very true to the perfume and the bottles look just like their corresponding perfume bottle.

Is hair mist harmful?

Can perfumes damage your hair? The answer is YES! That’s because perfumes contain harsh alcohols, including ethyl alcohol, and heavy synthetic fragrances. According to the Food and Drug Administration (FDA), ethyl alcohol can really dry out your skin and hair.

How long is Army Delayed Entry Program?

365 days
In most cases, recruits may be in delayed entry status as a Future Soldier for a few months to as long as one year. In general, you may not be on DEP status for more than 365 days. DEP enlistees can expect to participate in Army fitness programs while they wait to ship out.

What is the military Delayed Entry Program?

Most people who enlist join through the Delayed Entry Program(DEP) sometimes called the Future Soldiers Program. This allows someone to sign up for the military prior to the date when they will ship out for initial training. People in the DEP are unpaid and are not subject to the Uniform Code of Military Justice, UCMJ.

Do you get paid while in the Army Delayed Entry Program?

Do you get paid while in the DEP? The Delayed Entry Program is not technically an active or reserve program. Until you sign your contract and attend training, you do not generate Military pay or receive Military benefits. Some DEP Programs will pay for certain items.

Do you go to MEPS before DEP?

Some people will go into their branch’s delayed entry program (DEP) and go home after MEPS to wait until their ship-out date. Others will embark to basic training immediately after MEPS. Remember, you have not joined the military before going to MEPS, but by the end of it, you will be asked to.

Is Delayed Entry Program considered active duty?

Enlistees first enter the DEP as inactive reservists, then make a commitment to report for training on a specified date. However, they do not become active-duty servicemembers until they formally enlist as such on that date.

Is the Delayed Entry Program mandatory?

Some recruiting stations have those requesting a DEP discharge meet with the recruiting commander or a discharge board, where you will be pressured to change your mind. Such meetings are not mandatory.

Can you quit the military after MEPS?

If you have NOT been to the Military Entrance Processing Station (MEPS) and have NOT taken an Oath of Enlistment, you are free to quit the process at any time. Just because you arrive at MEPS does not mean you are fully committed with no chance of deciding not to commit after all.

How long can you be in the delayed entry program?

The most common reasons for delayed entry are to finish high school or meet some other eligibility requirement. The maximum time allowed for delayed entry is ​ 365 days ​. During that time, you are encouraged to attend meetings, classes and other activities at the recruiting office.

Do you get paid in delayed entry program?

Until you sign your contract and attend training, you do not generate Military pay or receive Military benefits. What is DEP in the Air Force? The Delayed Entry Program ( DEP ) allows you to complete your application to the Air Force and reserve your Air Force job before an assignment is available.

Can I get out delayed entry program?

Yes and no. If you are in the Delayed Entry Program and wish to join another branch of service, you must first submit request to exit the Delayed Entry Program of the service you are in. So, while you can enter into another branch, there is not currently a process to switch to another service.

Does delayed entry Army mean active duty?

What is DEPS military? The Delayed Entry Program ( DEP , also called the Delayed Enlistment Program or Future Soldiers Program in the Army), is a program whereby individuals going into active duty in the United States Armed Forces enlist first in the DEP before they ship out to Basic Training.

How does restriction enzyme mapping work?

Restriction mapping is a method used to map an unknown segment of DNA by breaking it into pieces and then identifying the locations of the breakpoints. This method relies upon the use of proteins called restriction enzymes, which can cut, or digest, DNA molecules at short, specific sequences called restriction sites.

What is BamHI restriction site?

BamHI (pronounced “Bam H one”) (from Bacillus amyloliquefaciens) is a type II restriction endonuclease, having the capacity for recognizing short sequences (6 bp) of DNA and specifically cleaving them at a target site.

Does HaeIII produce sticky ends?

Sau3A – recognises the sequence 5’GATC’3 (produces the same sticky ends as BamHI upon cutting) HaeIII – recognises the sequence 5’GGCC’3 – blunt ends.

What is the purpose of restriction mapping?

What is enzyme BamHI?

BamHI is a type II restriction enzyme derived from Bacillus amyloliquefaciens. Like all Type II restriction endonucleases, it is a dimer and the recognition site is palindromic and 6 bases in length. It recognizes the DNA sequence of G’GATCC and leaves an overhang of GATC which is compatible with many other enzymes.

What is DNA mapping with restriction enzymes?

DNA mapping: DNA mapping using restriction enzymes (also known as restriction mapping) is a method to obtain structural information of the DNA fragment. In this technique the DNA is digested with a series of restriction enzymes to produce DNA fragments of various sizes.

What are the factors affecting the activity of restriction enzymes?

The digestion activity of restriction enzymes depends on the following factors: Temperature: Most endonucleases digest the target DNA at 37 °C with few exceptions. Some work at lower temperatures (~25 °C, Sma 1) while Taq I works at 65 °C.

How do you create a restriction map of a sequence?

Restriction Map Generator This tool analyzes a DNA sequence to identify Restriction Enzyme Sites and generate a comprehensive map overview of their locations within the DNA sequence. Enter a DNA sequence in the box below to analyze the sequence for restriction sites and generate a restriction map.

What is the pH range of restriction enzymes?

Buffer systems: Most restriction enzymes are active in the pH range of 7.0–8.0. Tris-HCl, a temperature-dependent buffer, is the most commonly used buffer. Methylation status of DNA: Methylation of adenine or cytidine residues affects the digestion of DNA.

What is the most accurate power meter for cycling?

Best Power Meters

• Garmin Rally RS200 power pedal. The complete power meter pedal system.
• Favero Assioma Duo pedals. Accurate and affordable for multiple bike owners.
• Wahoo Powrlink Zero power meter pedals.
• SRM X-Power pedals.
• Rotor INspider.
• Quarq DZero.
• Stages Power LR Ultegra R8000.
• SRM Origin.

What power meters do pro cyclists use?

Best power meters reviewed

• Quarq DZero DUB Power Meter Spider. Best crank based power meter.
• S-Works Power Cranks. Best high-end crank-based power meter.
• Shimano Dura-Ace R9100-P power meter.
• FSA Powerbox power meter.
• Favero Assioma Duo Pedals.
• Garmin Rally pedals.
• 4iiii Precision power meter.

What power meter does Chris Froome use?

Stages LR
The double-sided power meter used by Chris Froome for his past three Grand Tour victories has finally been brought to market. The Stages LR is the first dual-sided power meter to have been developed by the brand and was first used on Froome’s Tour de France winning bike in 2016.

Does Shimano make power meters?

Shimano’s DURA-ACE Power Meter uses Bluetooth/ANT+ technology to pair to your cycling computer giving you live power data.

How accurate is 4iiii power meter?

4iiii Precision power meter: accuracy At the heart of any power meter is accuracy and 4iiii claims +/- 1%.

How accurate is strava power?

According to Strava’s algorithms I averaged 343 watts for this three hour ride. From many years worth of rides in the legs, I can confirm that Strava’s estimated power data ranges from “somewhat accurate” to “wildly ridiculous” (and everything in between).

Do Tour de France riders use power meters?

Just like its domination in the groupset stakes (used by 14 out of the 19 WorldTour teams), Shimano also dominates the power meter representation on WorldTour bikes, and at the Tour de France, 13 of the 22 teams are using Shimano’s R9100-P power meter crankset, which measures left and right leg power independently for …

Do Tour de France riders use bike computers?

Wahoo Elemnt Bolt bike computer The pro peloton rely on closely monitoring their individual performances while racing the Tour de France, and that’s where bike computers come in.

Can Chris Froome comeback?

Froome has built his comeback and his move to the Israel Start-Up Nation team on targeting the Tour de France, even if there are no signs he will be competitive and able to challenge the likes of Tadej Pogačar, Primož Roglič or former teammate Geraint Thomas.

What watch does Chris Froome wear?

Starting with this year’s winner, Chris Froome, who’s often seen wearing a Rolex Sea-Dweller 16600. We went through the Instagram accounts of the top cyclists and found some snaps of them in their watches. Rolex Sea-Dweller 16660.

Does Wahoo have a power meter?

After many years of Speedplay fans begging for it, and nearly a year after it was initially teased, Wahoo has officially launched the Speedplay Powerlink Zero power meter pedal system.

Does 4iiii work with Garmin?

Setting up. Setting up the 4iiii Precision is simple: you take off your existing crank, you put this one on, and that’s yer lot. It transmits via both Bluetooth Smart and ANT+ so it’ll talk to the vast majority of devices you’re likely to want to use, including Garmin Edge computers and your mobile phone.