What is the goal of statin therapy?
Based on high-quality evidence from randomized controlled trials (RCTs), high-intensity statin therapy should be instituted with a goal of lowering LDL-C levels by 50% or more in patients with ASCVD up to 75 years of age.
What is a moderate intensity statin?
Moderate-intensity statin therapies include atorvastatin (10–20 mg), rosuvastatin (5–10 mg), simvastatin (20–40 mg), pravastatin (40–80 mg), and several others. — With few exceptions, use of lipid-modifying drugs other than statins is discouraged.
Who needs a moderate intensity statin?
In persons 40 to 75 years of age without clinical ASCVD or diabetes and with an estimated 10-year ASCVD risk of 7.5% or greater, moderate- to high-intensity statin therapy should be used. If the 10-year risk of ASCVD is 5% to less than 7.5%, treatment with a moderate-intensity statin is reasonable.
What are the new cholesterol guidelines 2020?
The LDL-cholesterol goal <55 mg/dL (1,4 mmol/L) in 2020 ISG guidelines is only mentioned in the subgroup of hypertension and coronary artery disease (CAD) patients, but as listed above, this is only minority of those considered to be treated according this goal in 2019 ESC/EAS guidelines on dyslipidaemias.
What is the goal of statin therapy for high risk patients?
Lowering LDL cholesterol (LDL-C) with statins decreases cardiovascular risk; therefore LDL-C is the primary target in lipid therapy. The amount of risk reduction is the greater, the lower the LDL-C values achieved by statin therapy are.
When is statin therapy indicated?
For most patients with an LDL-C >100 mg/dL (>2.59 mmol/L) and a 10-year cardiovascular disease (CVD) risk of 10 percent or greater, we initiate statin therapy.
What is low intensity statins?
For the purpose of this guideline, statins are grouped into 3 different intensity categories according to the percentage reduction in low-density lipoprotein cholesterol: a 20% to 30% reduction is low intensity. a 31% to 40% reduction is medium intensity. a reduction of more than 40% is high intensity.
Who should get high intensity statins?
High-intensity statins are recommended for 2 categories of patients: those with ASCVD (secondary prevention) and high-risk patients without clinical ASCVD. Most patients with ASCVD are candidates for high-intensity statins, with a goal for low-density lipoprotein cholesterol reduction of 50% or greater.
What is the optimal goal for LDL cholesterol?
The optimal guideline level of LDL cholesterol is less than 100 mg/dl. Research from the Cleveland Clinic (REVERSAL study) compared two cholesterol lowering drugs (pravastatin and atorvastatin) and found that lower levels of LDL, as low as 60 mg/dl had better outcomes.
What is the goal for LDL blood cholesterol levels?
The goal for LDL cholesterol in this risk category is <160 mg/dL. The primary aim of therapy is to reduce long-term risk. When baseline LDL cholesterol is ≥160 mg/dL, persons are started on dietary therapy for three months.
What is the LDL goal?
LDL Goal: less than 100 mg/dl with a therapeutic option of treating to under 70 mg/dL. For very high-risk patients whose LDL levels are already below 100 mg/dL, there is also an option to use drug therapy to reach the less than 70 mg/dL goal.
What cholesterol level needs statins?
Low-density lipoprotein (LDL) cholesterol. If your risk is very low, you probably won’t need a statin, unless your LDL is above 190 mg/dL (4.92 mmol/L). If your risk is very high — for example, you’ve had a heart attack in the past — a statin may be helpful even if you don’t have high cholesterol.
Which statins are high intensity?
— High-intensity statin therapies are atorvastatin (40–80 mg) or rosuvastatin (Crestor; 20–40 mg). Moderate-intensity statin therapies include atorvastatin (10–20 mg), rosuvastatin (5–10 mg), simvastatin (20–40 mg), pravastatin (40–80 mg), and several others. In respect to this, what does high intensity statin mean?
What is the lowest dose of statin?
“Leqvio is a revolutionary approach to lower LDL-C and creates new possibilities for how health care systems can impact cardiovascular disease, a defining public health challenge of our time,” said Vas Narasimhan, MD, CEO of Novartis, in the press release.
Which statin is the best choice for which patient?
lowering cholesterol
When to increase statin dose?
Statins do not boost recovery from COVID-19 and may actually increase risk for death in those with severe disease, according to a new study. File Photo by ragonmages/Shutterstock