How do platinum chemotherapy drugs work?
Platinum-Based Drugs (Cisplatin, Carboplatin) These drugs form highly reactive platinum complexes that bind and crosslink DNA, a double-stranded molecule inside the nucleus of the cell that controls cellular activity. The chemical crosslinking within the DNA prevents cancer cells from growing and causes them to die.
What is the ligand in cisplatin?
It has two chloride ion ligands situated adjacent to one another, and two remaining ammonia ligands likewise, in a square (tetragonal) planar structure….Platinum(II) Complexes & Cisplatin.
| Sensitivity | Type of Cancer |
|---|---|
| Limited activity | Melanoma, breast |
How is cisplatin synthesized?
The common starting material for these procedures is K2[PtCl4], a water-soluble salt, which can be prepared directly from platinum metal in two steps. As with Peyrone’s initial synthesis, several protocols for the synthesis of cisplatin involve the direct action of aqueous ammonia on the tetrachloroplatinate ion.
What is pt II?
Description. Platinum(2+) is a divalent metal cation, a platinum cation and a monoatomic dication. ChEBI. Platinum (II) ion is a natural product found in Arnica montana with data available.
What cancers are treated with platinum?
The platinum compounds are largely used in the treatment of lung, breast, ovarian, and colon cancers. The chemotherapeutic mechanism of platinum compounds is typical of DNA-binding alkylating agents. If the DNA damage exceeds the ability of the cell to repair, the cell undergoes apoptotic cell death.
How effective is platinum chemotherapy?
The 1-year survival rate was increased by 5% with platinum-based regimens (34% v 29%; OR, 1.21; 95% CI, 1.09 to 1.35; P = . 0003).
How many ligands are in cisplatin?
Structure/Function: Cisplatin has a square planar platinum center that coordinates four ligands, two chloride and two ammonium. The cis formation of this compound is responsible for the anticancer activity exhibited in tumor cells.
Is cisplatin inert or labile?
On cisplatin, the two Pt-NH3 bonds are kinetically inert and thermodynamically stable, while the Pt-Cl bonds are semi-labile and can act as leaving groups for nucleophiles. Lability refers to the rate at which the ligands can be replaced with other molecules.
Why is cisplatin square planar?
Although some students of organic chemistry may be accustomed to interpreting a tetracoordinate atom as a flattened tetrahedron, cisplatin has a square planar geometry. This shape minimizes repulsive interactions between electrons in the d orbitals.
Who produces cisplatin?
Cisplatin | compare suppliers & send inquiries for free
| Shandong Octagon Chemicals Limited MOQ: 25 g Type: Distributor Produced in: China | MOQ: 25 g Distributor | − |
|---|---|---|
| Heraeus Type: Producer Produced in: Germany | Producer | |
| Sicor De México Type: Producer Produced in: Mexico | Producer | − |
| Cipla Type: Producer Produced in: India | Producer |
What is the element name of Pt?
Platinum
Platinum, Pt, is an element in group 10, period 6, on the periodic table with the atomic number 78. Platinum is a heavy, malleable, ductile, grey-white transition metal, used in many ways. Platinum; Pt; a silvery white metal when pure.
What is the charge of Pt element?
platinum
| atomic number | 78 |
|---|---|
| boiling point | 3,827 °C (6,920 °F) |
| specific gravity | 21.45 (20 °C) |
| oxidation states | +2, +4 |
| electron configuration | [Xe]4f145d96s1 |