Is febuxostat better than allopurinol?
Conclusions. Febuxostat, at a daily dose of 80 mg or 120 mg, was more effective than allopurinol at the commonly used fixed daily dose of 300 mg in lowering serum urate. Similar reductions in gout flares and tophus area occurred in all treatment groups.
Which is safer febuxostat or allopurinol?
We consider that febuxostat is a safer therapy than allopurinol in CKD patients since some studies have demonstrated they have an increased risk of allopurinol-induced adverse reactions [3].
Is there an alternative drug to allopurinol?
Febuxostat, like allopurinol, is a xanthine oxidase inhibitor that can lower urate levels in patients with gout and thus prevent acute attacks. It has become the usual first alternative for allopurinol-intolerant patients with gout.
What is the best medicine for gout pain?
Your doctor may recommend colchicine (Colcrys, Gloperba, Mitigare), an anti-inflammatory drug that effectively reduces gout pain. The drug’s effectiveness may be offset, however, by side effects such as nausea, vomiting and diarrhea. Corticosteroids.
How is gout treated in patients with tophi?
Treating gout with urate-lowering medications is strongly recommended for patients who have tophi (nodules that form from a mass of uric acid crystals at joints or in soft tissues), radiographic evidence (X-ray or other imaging) of damage due to gout, or two or more gout flares per year.
What is the goal of gout treatment?
Gout treatment has 2 overarching goals: alleviating the pain and inflammation caused by acute gout attacks and long-term management that is focused on lowering serum urate (sUA) levels to reduce the risk of future attacks.
How do you treat ophthalmomyiasis externa?
The mainstay of treatment for ophthalmomyiasis externa is the removal of the larvae, often at the slit lamp, with topical analgesics and antibiotics. Removal of the larvae may be difficult due to their strong attachment to tissue using their oral hooks and body spicules.