Is leukotriene B4 chemotactic?

Is leukotriene B4 chemotactic?

Leukotriene B4(LTB4)1 is a potent chemoattractant that is primarily involved in inflammation, immune responses and host defence against infection2.

What is a function of leukotriene B4?

Leukotriene B4 induces recruitment and activation of neutrophils, monocytes and eosinophils. It also stimulates the production of a number of proinflammatory cytokines and mediators indicating an ability to augment and prolong tissue inflammation.

Which leukotriene is chemotactic for neutrophils?

LTB4
LTB4 is a potent chemotactic agent for neutrophils and other leukocytes and promotes expression of cell adhesion proteins.

Which leukotriene is a chemotactic?

Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence. Blood.

What is chemotactic movement?

Chemotaxis is defined as cell movement toward a gradient of increasing chemical concentration (Lauffenburger and Zigmond, 1981).

What are chemotactic agents?

Chemotactic factors are mediators that induce unidirectional leukocyte movement by establish- ing a concentration gradient of the chemotactic factor that increases toward an area of inflamma- tion. A number of different types of molecules can act as chemotactic factors (Table 1).

What is neutrophil chemotaxis?

The directed migration of neutrophils, referred to as chemotaxis, requires the temporal and spatial regulation of intracellular signaling pathways allowing the neutrophil to detect a gradient of attractant, polarize, and migrate rapidly toward the highest concentration of the chemoattractant.

How do leukotrienes differ from histamine?

In the mechanism of allergic rhinitis, histamine is responsible for major allergic rhinitis symptoms such as rhinorrhea, nasal itching and sneezing. Its effect on nasal congestion is less evident. In contrast, leukotrienes result in increase in nasal airway resistance and vascular permeability.