What are suppositories made of?
Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. As the warmth of your body melts the outside, the drug slowly releases. Different types of suppositories go into the rectum, vagina, or the duct that empties your bladder, called the urethra.
Why is Glycerinated gelatin The preferred vaginal suppository base?
Compounded vaginal inserts that use water-soluble bases, such as polyethylene glycol (PEG) or glycerinated gelatin, are the preferred form because they minimize leakage.
What is the composition of Glycero gelatin base?
Glycerogelatin bases:These comprise a mixture of glycerol and water, which is stiffened with gelatin. The commonest in use is glycerol suppositories BP which has 14% w/w gelatin and 70% w/w glycerol. In hot climates, the gelatin content can be increased to 18 % w/w.
How are vaginal suppositories made?
Fusion Molding involves first melting the suppository base, and then dispersing or dissolving the drug in the melted base. The mixture is removed from the heat and poured into a suppository mold. When the mixture has congealed, the suppositories are removed from the mold.
What is the active ingredient in most laxative suppositories?
Drug Facts
| Active ingredient (in each suppository) | Purpose |
|---|---|
| Bisacodyl USP 10 mg ….. | Stimulant laxative |
What is a glycerin suppository?
Glycerin suppositories are known as stimulant laxatives. They should only be used to provide rapid relief from temporary constipation. They should not be used to treat chronic (long-term) constipation (unless recommended by your doctor).
How will Glycerinated gelatin and glycerin suppositories be stored?
Glycerinated gelatin suppositories require storage in tight containers, preferably at a temperature below 35 . Several combinations of polyethylene glycols having melting temperatures that are above body temperature have been used as suppository bases.
What is the use of Glycerogelatin base?
What is the use of Glycerogelatin base? It is used as a base for suppositories and urethral bougies which contain a mixture of gelatin (14 parts), glycerin (70 parts) and water(16 parts).
What is Glycero gelatin suppository?
Glycerol Suppositories are used for the relief of acute and temporary constipation in infants, children and adults. Glycerol belongs to a group of medicines called laxatives. A laxative is a medicine which is used for the treatment of constipation.
What is Dulcolax suppository made of?
Dulcolax suppository contains 10 mg of bisacodyl as the active ingredient. Inactive ingredient: hard fat as the suppository base.
What is the difference between glycerin suppository and Dulcolax suppository?
Dulcolax® suppositories stimulate a strong, wave-like movement of rectal muscles, but they are much more habit-forming than glycerin suppositories. These agents must be carefully placed against the rectal wall to be effective. If inserted into the stool, no action will occur.
What is the formulation of suppositories?
The suppository dosage form Lipophilic suppositories are primarily fat- or wax-based and melt at human body temperature. Hydrophilic suppositories are polymer or glycerin based and require fluids to dissolve. Suppository drug delivery is via passive diffusion from the dosage form into the vaginal or rectal tissue.
