What are the limitations of the typhidot test?
The most important limitation of this test is that it is not quantitative and result is only positive or negative hhj8b . Whereas a detailed Widal test can tell the titres of specific antibodies. However both tests lack sensitivity and specificity.
What is the most accurate test for typhoid fever?
Bone marrow culture is the most accurate diagnostic test for typhoid fever however is invasive and not feasible in many settings. New vaccines for typhoid and the need for improved estimates of burden increases the demand for improved understanding of diagnostic accuracy.
Which is more accurate widal or typhidot?
We conclude that the Dot-EIA (enzyme immunoassay; typhidot) is a more sensitive and specific test which is easy to perform and more reliable compared to the Widal test and that it is useful in early therapy.
What is the sensitivity of Widal test?
Widal test recorded 81.5% sensitivity, 18.3% specificity, 10.1% positive predictive value and 89.7% negative predictive value. Stool culture showed 31.3% sensitivity, 91.5% specificity, 29% positive predictive value and 91.5% negative predictive value.
Why Typhidot is obsolete?
Even though Typhidot is rapid, easy and affordable, its use should be discouraged due to low sensitivity and specificity and insignificant (p=0.067) association to the disease.
Why Typhidot test is done?
The typhoid screening test is a used to identify, diagnose & monitor of fever and other salmonella infections. This is conducted to detect antibodies against the infection.
Is Typhidot test reliable?
A reliable, easy and affordable rapid diagnostic test is a need for our clinicians, many of whom consider Typhidot to be promising. Typhidot has been used as the only tool to diagnose typhoid fever by general practitioners and consultants despite its low sensitivity and specificity causing misdiagnosis and treatment.
What is the difference between Widal test and Typhidot test?
Widal test showed sensitivity and specificity of 53% and 83% on blood culture proven cases. Typhidot test showed sensitivity and specificity of 93% and 83%, respectively on blood culture proven cases. Conclusion: Using blood culture as the gold standard, typhidot showed a higher sensitivity compared to Widal test.
Is typhidot test reliable?
Why typhidot test is done?
Is Typhidot test same as Widal test?
The Widal test is both quantitative as well as qualitative and it can tell the titres of specific antibodies. The typhidot separately identifies IgM and IgG antibodies against the bacteria. IgM shows recent infection where as IgG signifies remote infection. The Typhidot test only gives result as positive or negative.
Is Widal test specific or non specific?
While the method is easy to perform, concerns remain about the reliability of the Widal test. It is not specific for typhoid fever and can be positive when a person does not have the infection.
What is the sensitivity of Typhidot in patients with other diseases?
Amongst the 130 patients with diseases other than typhoid, 50(38.5%) showed a positive Typhidot result. Amongst the 15 patients with typhoid, 11(73.3%) showed a negative Typhidot result. The sensitivity of Typhidot was found to be 26.7% and the specificity was 61.5%.
How accurate is The typhidot test?
Of the 30 culture positive samples, 27 were positive by Typhidot. The Typhidot test gave a sensitivity of 100 per cent and specificity of 80 per cent when bacteraemic patients were analysed. Interpretation & conclusion: The Typhidot is easy to perform, and requires no special equipment or training of staff for interpretation of results.
What does a negative a typhidot test mean?
A typhidot-M test is another variation of the typhidot test that helps in the diagnosis of the acute phase of typhoid infection. Normal results: A negative result for anti-salmonella IgG and IgM antibodies indicates no infection. A positive result for IgM antibodies indicates acute infection.
Does Typhidot cause positive IgG and IgM?
Results: Typhidot test was positive for both IgG and IgM in 39 samples, IgM alone in 24 and IgG alone in 2. Of the 30 culture positive samples, 27 were positive by Typhidot.