What does indeterminate QuantiFERON gold mean?

What does indeterminate QuantiFERON gold mean?

An indeterminate result indicates an uncertain likelihood of M. tuberculosis infection. A borderline test result (T-Spot only) also indicates an uncertain likelihood of M. tuberculosis infection.

What is the normal range for QuantiFERON-TB Gold?

Quantiferon-TB Gold Plus (QFT-Plus) is an interferon gamma release assay used to diagnose latent tuberculosis (LTB). A borderline range (0.20 to 0.99 IU/ml) around the cutoff (0.35 IU/ml) has been suggested for the earlier QFT version.

What if TB Gold test is indeterminate?

The test was considered indeterminate if the mitogen response was <0.5 IU/ml together with TB response <0.35 IU/ml or ⩾0.35 IU/ml and <25% of nil value, or nil response >8.0 IU/ml, as recommended by the manufacturer’s criteria.

What do you do if QuantiFERON gold is indeterminate?

An indeterminate QFT-G result does not provide useful information regarding the likelihood of M. tuberculosis infection. The optimal follow-up of persons with indeterminate QFT-G results has not been determined. The options are to repeat QFT-G with a newly obtained blood specimen, administer a TST, or do neither.

What does an indeterminate result mean to a patient?

Listen to pronunciation. (IN-deh-TER-mih-nut reh-ZULT) A negative test result in an individual where a clearly deleterious mutation has not been found in any family members.

What is normal TB mitogen level?

Components Reference Interval
QuantiFERON-TB Gold In-Tube Negative
QuantiFERON-TB1 minus NIL 0.34 IU/mL or less
QuantiFERON-TB2 minus NIL 0.34 IU/mL or less
QuantiFERON MITOGEN minus NIL No reference interval

What are normal mitogen levels?

now? Remember: To be valid the mitogen result should be > 0.5 for a negative or an indeterminate result with a normal nil. Otherwise any result over 0 is valid.

Does QuantiFERON need to be repeated?

Negative QFT results do not require confirmation, but results can be confirmed with either a repeat QFT or TST if the accuracy of the initial test is in question.

What causes indeterminate Quantiferon?

The indeterminate test results may be due to possible immunosuppression or due to some technical errors and is indicated by low mitogen response. The advanced age and underlying disease in patients receiving immunosuppressive treatment comprise the risk factors that can promote indeterminate results on QFT-G test.

How often should QuantiFERON gold test be done?

How often should providers be screened for TB infection? Most recommendations in low-prevalence countries, including those of the CDC, now consider that healthcare personnel should be screened once at hiring or at the beginning of their occupation (3).

How much does a QuantiFERON TB Gold test cost?

The cost of a Quantiferon TB Gold blood test in a laboratory setting will cost about $90 to $160 without a health insurance plan. The costs will depend on the lab you choose and if health insurance is involved. Accesalabs.com, for example, charges $149 for its test. WalkinLab.com, another lab online, will charge $148.

How to order Quantiferon Gold?

– a negative QFT-G or TST result >6 weeks after the end of exposure, – culture-confirmed TB disease <2 years after the end of exposure, and – an M. tuberculosis isolate that has a genotype identical to that of the presumed source case.

What does a positive Quantiferon Gold test mean?

The QuantiFERON -TB Gold test (QFT …. A positive result suggests that M. tuberculosis infection is likely; a negative result suggests that infection is unlikely; and indeterminate result suggests QFT-G results cannot be interpreted as a result of low mitogen response or high background response.

How long does Quantiferon Gold test take?

The QuantiFeron-TB Gold Plus, on the other hand, can confirm active tuberculosis infection. It uses highly specific TB antigens that aid in properly detecting the presence of TB infection in the blood. It takes a maximum of 24 hours to get the results.