What is CD44 a marker for?
CD44 cleavage, shedding, and elevated levels of soluble CD44 in the serum of patients is a marker of tumor burden and metastasis in several cancers including colon and gastric cancer. Recent observations have shown that CD44 intracellular domain (CD44-ICD) is related to the metastatic potential of breast cancer cells.
Is bt549 triple negative?
MDA-MB-157, MDA-MB-231, and BT-549 cells are characterized as triple-negative/basal-B mammary carcinoma, while the MDA-MB-468 cells are characterized as triple-negative/basal-A mammary carcinoma.
What is BT-474 cell line?
BT-474 is a cell line exhibiting epithelial morphology that was isolated from a solid, invasive ductal carcinoma of the breast obtained from a 60-year-old, White, female breast cancer patient. Use these cells in your cancer research.
What is MCF7 cell line?
MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [27].
What is CD62L marker?
CD62L/L-selectin is a marker found on naïve T cells and further distinguishes central memory (Tcm, CD62L+) from effector memory (Tem, CD62L−) T cells. The regulation of CD62L plays a pivotal role in controlling the traffic of T lymphocytes to and from peripheral lymph nodes.
Is CD44 a stem cell marker?
CD44 has consequently been recognized as a cancer stem cell marker in several types of cancers, which has been a topic of much recent research. In this review we have addressed the question of how CD44 might promote cancer cell stemness by interacting with extracellular matrix components, growth factors and cytokines.
Is MCF10A triple negative?
EGFR activating mutations mediate EGF-independent proliferation in MCF10A. As triple negative breast cancers (TNBC) have been found to harbour mutations in EGFR [28], we wished to determine how they affect a relatively normal breast cell line.
Where is hek293 from?
Human embryonic kidney 293 cells, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a specific immortalised cell line derived from a spontaneously miscarried or aborted fetus or human embryonic kidney cells grown in tissue culture taken from a female fetus in 1973.
What are t47d cells?
T-47D are epithelial cells isolated from a pleural effusion obtained from a 54-year-old female patient with an infiltrating ductal carcinoma of the breast. Use these cells in your breast cancer research. Homo sapiens, human.
How fast do MCF-7 cells grow?
MCF-7 human mammary carcinoma cells were inoculated into 150-sq cm flasks at 3 X 10(5) cells/flask, and after a lag period of about 48 hr, these cells grew exponentially for 5 days with a mean population doubling time of about 24 hr.
Is MCF-7 invasive?
Though MCF7 is categorized as poorly invasive, its migration in the 2D surface is found to be comparable to the highly invasive MDA MB 231 in the current study.
What does HBL 100 stand for?
A cell line (HBL-100) established from human breast milk A continuous cell line (HBL-100) was obtained from primary cultures of cells derived from an early lactation sample of human milk. There was no evidence of a breast lesion in the milk donor.
What is the IHC definition of basal tumors?
An immunohistochemical (IHC) definition of basal-like tumors has been developed based on a triple-negative phenotype (ER, PR and amplified HER-2/Neu negative) and expression of either epidermal growth factor receptor (EGFR) or cytokeratin 5/6 [48, 49].
How many TNBC are basal-like breast cancers?
For example, array based classification of 172 TNBC found that 123 (71%) were basal-like breast cancer and of 160 basal cancers 123 (77%) were TNBC [46]. These distinctions were important as the clinical outcomes were worse for the basal breast cancers than for the non-basal TNBC [47].
What is metastatic cancer?
Cancer that spreads from where it started to a distant part of the body is called metastatic cancer. For many types of cancer, it is also called stage IV (4) cancer.