What is Fragile X an example of?
Fragile X syndrome (FXS) is a genetic disorder. FXS is caused by changes in a gene that scientists called FMR1 gene when it was first discovered. The FMR1 gene usually makes a protein called FMRP.
What does having Fragile X mean?
Fragile X syndrome is a genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment. Usually, males are more severely affected by this disorder than females. Affected individuals usually have delayed development of speech and language by age 2.
Which parent gives Fragile X?
The gene for Fragile X is carried on the X chromosome. Because both males (XY) and females (XX) have at least one X chromosome, both can pass on the mutated gene to their children. A father with the altered gene for Fragile X on his X chromosome will pass that gene on only to his daughters.
How does fragile X affect learning?
Children and adults with full mutation fragile X may have problems with memory, abstract thinking, problem solving, and planning. Social and behavior problems, difficulty with learning, developmental delays, and autism spectrum disorder are common, as are anxiety and depression.
What is fragile X syndrome?
Fragile X syndrome is the most common form of inherited intellectual and developmental disability (IDD). People with Fragile X syndrome may not have noticeable symptoms, or they can have more serious symptoms that range from learning disabilities to cognitive and behavior problems.
How does fragile X affect learning and intelligence?
Intelligence and learning. Many people with Fragile X have problems with intellectual functioning. These problems can range from the mild, such as learning disorders or problems with mathematics, to the severe, such as an intellectual or developmental disability. The syndrome may affect the ability to think, reason, and learn.
What is the prevalence of hyperactivity in Fragile X syndrome?
Hyperactivity is common, and seizures occur in about 10%. Males are usually more affected than females. This disorder and finding of Fragile X syndrome has an X-linked dominant inheritance. It is typically caused by an expansion of the CGG triplet repeat within the FMR1 (fragile X mental retardation 1) gene on the X chromosome.
How many repeats of DNA are in Fragile X syndrome?
Normally, there are between 5 and 40 repeats; fragile X syndrome occurs with more than 200. A premutation is said to be present when the gene has between 40 and 200 repeats; women with a premutation have an increased risk of having an affected child.
