What is heparin-PF4 antibody?
A test for heparin-induced thrombocytopenia (HIT) antibody, also called heparin-PF4 antibody, is performed to detect antibodies that develop in some people who have been treated with heparin.
What is positive PF4?
A positive H/PF4 ELISA result has relatively low and uncertain predictive value for the development of clinical HIT-II. Clinical Picture of Immune HIT or HIT-like Syndromes: HIT in patients not previously exposed to heparin: 1) Decrease in platelet count (thrombocytopenia) of 50% from baseline or postoperative peak.
What is PF4 blood factor?
Abstract. Platelet factor 4 (PF4, CXCL4) is a small chemokine protein released by activated platelets. Although a major physiological function of PF4 is to promote blood coagulation, this cytokine is involved in innate and adaptive immunity in events when platelets are activated in response to infections.
What does PF4 stand for?
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) .
Why does heparin bind to PF4?
PF4 is an abundant chemokine present in the alpha granules of the platelets. PF4 can combine with the anticoagulant heparin to form an antigen that can induce the production of IgG antibodies. This immune complex of PF4-heparin and the IgG antibody can activate platelets by binding to the platelet FcRγIIA receptor.
What is PF4 Elisa?
The PF4 ELISA is a serologic assay that provides laboratory support for the clinical diagnosis of HIT, but it is often positive in patients who do not have the syndrome.
What is PF4 heparin Elisa?
Abstract. Heparin induced thrombocytopenia (HIT) is a serious complication of heparin therapy. The PF4 ELISA is a serologic assay that provides laboratory support for the clinical diagnosis of HIT, but it is often positive in patients who do not have the syndrome.
What is heparin used to treat?
Heparin is used to prevent or treat certain blood vessel, heart, and lung conditions. Heparin is also used to prevent blood clotting during open-heart surgery, bypass surgery, kidney dialysis, and blood transfusions.
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules.
When to hold heparin platelets?
Immediate cessation of all formulations of heparin is mandatory including heparin flushes,heparin coated catheters,heparinised dialysate and any other sources
What are the effects of heparin?
skin changes where the medicine was injected;
What is heparin primary action?
The mechanism of action of heparin is ATIII-dependent. It acts mainly by accelerating the rate of the neutralization of certain activated coagulation factors by antithrombin, but other mechanisms may also be involved. The antithrombotic effect of heparin is well correlated to the inhibition of factor Xa.