What is picornavirus replication?
Picornaviruses contain positive-sense, single-stranded RNA genomes and replicate in the cytoplasm of infected cells. As a result of the limited coding capacity of these viruses, cellular proteins are required by these intracellular parasites for both translation and genomic RNA replication.
How do virions replicate?
Viruses cannot replicate on their own, but rather depend on their host cell’s protein synthesis pathways to reproduce. This typically occurs by the virus inserting its genetic material in host cells, co-opting the proteins to create viral replicates, until the cell bursts from the high volume of new viral particles.
Where is the initial replication site of picornavirus?
The ingested virus replicates in susceptible tissues of the pharynx or gut. Enteroviral replication can be observed in lymphoid tissue of the small intestine within 24-72 hours of ingestion of the virus.
How is picornavirus treated?
Rest, hydration, nasal decongestants, and cough suppressants may be appropriate. Start treatment as early as symptoms are recognized, and continue for 4-5 days. Consider petrolatum-based ointment to nares to prevent painful maceration.
How do viruses replicate a level biology?
Key Points. Viral replication involves six steps: attachment, penetration, uncoating, replication, assembly, and release. During attachment and penetration, the virus attaches itself to a host cell and injects its genetic material into it.
What method do viruses use to replicate?
There are two processes used by viruses to replicate: the lytic cycle and lysogenic cycle. Some viruses reproduce using both methods, while others only use the lytic cycle. In the lytic cycle, the virus attaches to the host cell and injects its DNA.
Is poliovirus a picornavirus?
The viruses in this family can cause a range of diseases including the common cold, poliomyelitis, meningitis, hepatitis, and paralysis….Picornavirus.
| Picornaviridae | |
|---|---|
| Electronmicrograph of poliovirus | |
| Isosurface of a human rhinovirus showing protein spikes | |
| Virus classification | |
| (unranked): | Virus |
How the picornavirus enters the host cell?
The virion first binds to a cellular receptor and enters the host cell in an endosome. The viral genome is released into the cytoplasm from early endosomes. The viral VPg protein is cleaved off the genomic RNA by a host protein called “unlinkase,” and the RNA associates with ribosomes.