What is the pKa of piperazine?
Piperazine
| Names | |
|---|---|
| Acidity (pKa) | 9.8 |
| Basicity (pKb) | 4.19 |
| Magnetic susceptibility (χ) | -56.8·10−6 cm3/mol |
| Pharmacology |
What is the pKa of an amine group?
9.5 to 11.0
Most simple alkyl amines have pKa’s in the range 9.5 to 11.0, and their aqueous solutions are basic (have a pH of 11 to 12, depending on concentration).
What is the pKa of ch3nh?
10.63
For instance, here’s a pKa table where the pKa of methylamine (CH3NH2) is listed as 10.63.
How do I calculate pKa?
Calculate the pKa with the formula pKa = -log(Ka). For example, pKa = -log(1.82 x 10^-4) = 3.74.
Is piperazine a tertiary amine?
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists. ChemMedChem. 2009 Dec;4(12):2080-97.
What class of drug is piperazine?
Organic compoundPiperazine / Classification
What is the pKa of an amide?
Amide. pKa = -0.4. A protonated amide possesses the least acidic group of them all (CONH+), proof that the blinking resonance form has in this case an overwhelming contribution.
What is pKa of HCl?
-6.3
Definition of Strong Acids An example is hydrochloric acid (HCl), whose pKa is -6.3. This generally means that in aqueous solution at standard temperature and pressure, the concentration of hydronium ions is equal to the concentration of strong acid introduced to the solution.
How do you find pOH?
To find the pOH, simply subtract the pH from 14. In order to calculate the pOH, take the negative log of the hydroxide ion concentration. To find the pH, simply subtract pOH from 14.
How do you find pKa from pH and concentration?
pH is the sum of the pKa value and the log of the concentration of the conjugate base divided by the concentration of the weak acid.
What is the category of piperazine citrate elixir?
How Piperazine Citrate Elixir works. Piperazine belongs to class of drugs called anthelmintic. It works by paralyzing the worms and making them to pass in the stool. It is effective against the intestinal nematodes roundworm (Ascaris lumbricoides), pinworm and threadworm (Enterobius vermicularis).
Which drug contain piperazine ring?
Piperazine is a very popular motif in CNS drugs as shown in three atypical antipsychotics, one antidepressant, and one sedative hypnotic. Piperazine is also embedded in two tyrosine kinase inhibitors: imatinib (Gleevec™) and dasatinib (Sprycel™).