What stage is hepatocellular carcinoma?
Histologic grade (G)
| Stage | Performance Status | Tumor Stage |
|---|---|---|
| A4 | 0 | 3 tumors, < 3 cm |
| Stage B: Intermediate HCC | 0 | Large, multinodular |
| Stage C: Advanced HCC | 1-2 | Vascular invasion or extrahepatic spread |
| Stage D: End-Stage HCC | 3-4 | Any |
What are complications of hepatocellular carcinoma?
Hepatic complications of hepatocellular carcinoma include hepatic encephalopathy, portal vein thrombosis, worsening ascites, variceal bleeding, obstructive jaundice, and pyogenic liver abscess. Intraperitoneal bleeding is a life-threatening complication of HCC.
What is hepatocellular carcinoma with metastasis?
Hepatocellular carcinoma (HCC) is a highly malignant tumor, causing both intrahepatic and extrahepatic metastases. The extrahepatic metastasis occurs in one-third of patients with HCC and it is associated with a poor prognosis.
What stage is a 5cm liver tumor?
Stage 2: One liver tumor is present, and cancer has spread to nearby blood vessels; or there is more than one tumor in the liver, but none are larger than 5 centimeters (cm).
What is last stage of hepatocellular carcinoma?
Patients with end stage or terminal HCC are those presenting with tumors leading to a very poor Performance Status (ECOG 3-4) or Child-Pugh C patients with tumors beyond the transplantation threshold. Among HCC patients, 15-20% present with end stage or terminal stage HCC. Their median survival is less than 3-4 months.
How does hepatocellular carcinoma cause death?
The immediate cause of death was tumor progression in 40 patients; cirrhosis complications in 23 patients; treatment related complications in 6 and infectious complications in 14. Tumor related deaths were as follows: BCLC A 7 deaths; BCLC B 6 deaths, BCLC C 26 deaths and BCLC D 18 deaths.
Does HCC metastasis to brain?
HCC is one of the highly malignant neoplasms. Extrahepatic metastases are seen in 64% of patients with HCC. The lungs, regional lymph nodes, kidney, bone marrow and adrenals are common sites of HCC metastasis[1-3]. But, metastasis to brain and skull is extremely rare.
How long can you live with Stage 4 HCC?
In one small study of people with metastatic hepatocellular carcinoma, those whose liver cancer had spread to their lymph nodes or distant organs had an average survival rate of 4 and 11 months, depending on the severity of their liver damage and whether they received treatment.
What is the role of SMYD3 in hepatocellular carcinoma (HCC)?
Wang Y, Xie BH, Lin WH, Huang YH, Ni JY, Hu J, et al. Amplification of SMYD3 promotes tumorigenicity and intrahepatic metastasis of hepatocellular carcinoma via upregulation of CDK2 and MMP2. Oncogene. 2019;38:4948–61.
Is ANKHD1 required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma?
Zhou Z, Jiang H, Tu K, Yu W, Zhang J, Hu Z, et al. ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38:18.
What does SMYD3 do in cancer?
SMYD3 was originally described as an H3K4 methyltransferase that regulates the transcriptional activities of downstream genes involved in cancer progression. Furthermore, a large amount of evidence indicates critical roles for SMYD3 in the proliferation, invasion, and migration of different tumor cells.
Is smyd3-mediated S1PR1 activity involved in cancer cell development and progression?
We performed CCK8, colony formation, cell cycle, apoptosis, and transwell assays to explore whether SMYD3-mediated S1PR1 activity was involved in cancer cell development and progression. SMYD3 or S1PR1 was stably or transiently overexpressed or knocked down in HCC cells.