What were the results of the Cancer Genome Atlas?
Among the TCGA findings are the identification of many gene mutations involved in GBM, including three previously unrecognized mutations that occur with significant frequency; and the delineation of core pathways disrupted in this type of brain cancer.
What is the Pan-Cancer Atlas?
The Pan-Cancer Atlas reclassifies human tumor types based on molecular similarity, indicating that the cell of origin influences but does not fully determine tumor classification, which informs future clinical trial design and interpretation.
When was the Cancer Genome Atlas completed?
TCGA’s Pan-Cancer Atlas A collection of cross-cancer analyses delving into overarching themes on cancer, including cell-of-origin patterns, oncogenic processes, and signaling pathways. Published in 2018 at the program’s close.
What is TCGA cohort?
The Cancer Genome Atlas (TCGA) dataset provides a valuable reference for researchers with an interest in the genetic basis of bladder cancer.
Why did the Cancer Genome Atlas start?
The Cancer Genome Atlas began with a pilot to assessed the feasibility of a full-scale effort to systematically explore the entire spectrum of genomic changes involved in human cancer.
What is UCSC Xena?
Abstract. UCSC Xena is a visual exploration resource for both public and private omics data, supported through the web-based Xena Browser and multiple turn-key Xena Hubs.
How do you cite Pan-cancer Atlas?
An example of a proper acknowledgement is: “The results here are in whole or part based upon data generated by the TCGA Research Network: https://www.cancer.gov/tcga.”
Is the Cancer Genome Atlas finished?
Researchers funded by the National Institutes of Health have completed a detailed genomic analysis, known as the PanCancer Atlas, on a data set of molecular and clinical information from over 10,000 tumors representing 33 types of cancer.
What is TCGA used for?
The Cancer Genome Atlas (TCGA) is a project to catalogue the genetic mutations responsible for cancer using genome sequencing and bioinformatics.
What is Metabric?
The METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study identified ten subtypes of BC termed integrative clusters (IntClust), by joint analysis of copy number and expression data to detect the cis genomics.
How do I get TCGA data?
easiest way:
- go to cBioportal.
- click on the tumor type you want.
- on the right side click on “summary”
- on the top of the page you have “download data”
