How are MMPs regulated?
Matrix metalloproteinase (MMP) activity is tightly regulated at four different levels: 1) gene expression, mainly by regulating transcription and mRNA stability, 2) compartmentalisation (as light yellow filled eclipse), which regulates efficiency of proteolysis through cell surface recruitment, substrate availability …
What does TIMP 1 inhibit?
TIMP-1 inhibits MMP activity through the binding of its N-terminus with the targeted MMP, resulting in chelation of Zn2+ from the enzyme active site (Gomis-Rüth et al., 1997).
What is a TIMP?
a set of kettledrums, two or more in number. Often (informal) shortened to: timps.
Is TIMP 1 a cytokine?
The present review summarizes the current knowledge on TIMP-1 as a cytokine modulator of cell functions, outlines recent progress in defining molecular pathways that transmit TIMP-1 signals from the cell periphery into the nucleus, and discusses TIMP-1’s role as a cytokine in the pathophysiology of cancer and other …
How do Metalloproteases work?
Metalloproteases (metallo, metal) are members of a clan of proteases that contain a metal ion at their active site which acts as a catalyst in the hydrolysis peptide binds.
What is the function of TIMP1?
TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). In regulating MMPs, TIMP1 plays a crucial role in extracellular matrix (ECM) composition, wound healing, and pregnancy.
Where is the TIMP gene located in the human body?
This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. In adrenocortical cells the trophic hormone ACTH induces expression of TIMP-1 and the increase in TIMP expression is also associated with decreased collagenase activity.
What is the prognosis of increased expression of TIMP1?
Increased expression of TIMP1 has been found to be associated with worse prognosis of various tumors, such as laryngeal carcinoma or melanoma. ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.