How do you give IV aminophylline?
Add 500mg to 500mL or 250mg to 250mL of a compatible infusion fluid (1mg/mL). Administer using a rate controlled infusion pump. Aminophylline infusions should be continued for at least 24 hours with review by medical staff at agreed intervals, and may be continued for a further 24-48 hours.
How do you calculate aminophylline infusion?
Converting IV aminophylline to ORAL aminophylline: Calculate the total amount administered in 24 hours by multiplying the hourly infusion rate by 24. This calculation assumes infusion concentration prepared is 1mg/ml.
Can aminophylline be given IV push?
Aminophylline Injection B.P. 250mg/10ml is for slow intravenous administration. The solution may be injected very slowly, or it may be infused in a small volume of either 5% dextrose or 0.9% sodium chloride injection. Aminophylline should not be administered concomitantly with other xanthine drugs.
Does aminophylline increase heart rate?
Does Aminophylline increase heart rate? Aminophylline increases the heart rate and contractility of a patient. According to clinical studies, Aminophylline or theophylline medication is administered to a COPD patient orally. It enhances both right and left heart systolic pump function.
Can theophylline be given IV?
Intravenous (IV) Patients can be administered IV theophylline for acute bronchospasm. Those who are not currently taking theophylline should be given a loading dose of 5 to 7 mg/kg intravenously, followed by a maintenance dose of 0.4 to 0.6 mg/kg per hour intravenously to maintain serum concentrations at 10 to 15 mg/L.
How is quinine infusion calculated?
To calculate the rate of quinine infusion is simple since quinine is to be given in 500 ml of 10% dextrose solution, to be administered over 4 h (i.e., we have to administer 500 ml of 10% dextrose solution with the required dose of quinine over 4 h).
What is the difference between aminophylline and theophylline?
Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi, produces diuresis, and causes an increase in gastric secretion. Aminophylline is the ethylenediamine salt of theophylline.
Does theophylline increase blood pressure?
Hemodynamics and Ventilation. In healthy subjects, theophylline increased heart rate and systolic blood pressure, but this effect was not significant compared with placebo (Table 4).
Does theophylline increase heart rate?
In noncontrolled studies performed in patients with symptomatic SSS, oral theophylline increased resting and exercise heart rate, improved symptoms, and reduced cardiac pauses during follow-up.
How can theophylline be administered?
Theophylline comes as an extended-release (long-acting) tablet, extended-release capsule, and a solution (liquid) to take by mouth. It usually is taken every 6, 8, 12, or 24 hours.
How much theophylline do you give a patient?
Those who are not currently taking theophylline should be given a loading dose of 5 to 7 mg/kg intravenously, followed by a maintenance dose of 0.4 to 0.6 mg/kg per hour intravenously to maintain serum concentrations at 10 to 15 mg/L.
Is IV theophylline effective in the treatment of acute asthma?
Our study has comprehensively reviewed the combined evidence for the efficacy and safety of IV theophylline in acute asthma. We found that theophylline somewhat reduced the heart rate and duration of stay, and was not significantly worse than adrenaline, beta-2 agonists, and leukotriene receptor antagonists.
What are the side effects of IV theophylline?
Compared with placebo, IV theophylline caused more nausea, vomiting, and cardiovascular adverse events (such as palpitations and arrhythmias) (Figure 11A). There were no differences in abdominal pain, psychological side effects, headaches, seizures, or tremor.
When should theophylline levels be measured after infusion?
-When administered intravenously, patients who have not had theophylline in the prior 24 hours should have theophylline concentrations measured 30 minutes after the end of the infusion; concentrations under 10 mcg/mL indicate an additional loading dose is needed; concentrations over 20 mcg/mL need to delay starting the constant infusion.