How does TB cause pleural effusion?
Tuberculous pleural effusion (TPE) results from Mycobacterium tuberculosis infection of the pleura and is characterized by an intense chronic accumulation of fluid and inflammatory cells in pleural space (2). So far, no formal guidelines are available for diagnosis and treatment of tuberculous pleurisy.
Can spinal TB cause pleural effusion?
Spinal tuberculosis or Pott’s disease of the spine associated with pleural involvement has for long intrigued the researchers regarding the nature and pathogenesis of their occurrence. Pleural effusion secondary to large extra-pleural extension of paravertebral abscess has been described in a series published in 1955.
Does TB cause unilateral pleural effusion?
It is the commonest cause of exudative pleural effusion in countries endemic to tuberculosis, such as Malaysia [7, 8]. Patients with TPE typically present with acute or subacute symptoms of fever, unilateral pleuritic chest pain, cough, night sweats, dyspnoea and weight loss [9].
What does tuberculosis do to the lungs?
TB is caused by the bacterium M tuberculosis. The infection destroys patients’ lung tissue, causing them to cough up the bacteria, which then spread through the air and can be inhaled by others. The mechanism behind this lung damage is poorly understood.
Is pleural effusion tuberculosis?
Tuberculous pleural effusion occurs in approximately 5% of patients with Mycobacterium tuberculosis (TB) infection1 and accounts for 4% of all TB cases in the United States. Diagnosis is challenging, with 48–96% of tuberculous pleural effusions negative by sputum acid-fast bacilli (AFB) stain and culture.
What is pleural TB?
Globally, pleural TB remains one of the most frequent causes of pleural exudates, particularly in TB-endemic areas and in the HIV positive population. Most TB pleural effusions are exudates with high adenosine deaminase (ADA), lymphocyte-rich, straw-coloured and free flowing, with a low yield on mycobacterial culture.
What is TB in bones?
Bone TB occurs when you contract tuberculosis and it spreads outside of the lungs. Tuberculosis is normally spread from person to person through the air. After you contract tuberculosis, it can travel through the blood from the lungs or lymph nodes into the bones, spine, or joints.