How is cytarabine given?
Cytarabine comes as a powder to mixed with liquid to be injected intravenously (into a vein), subcutaneously (under the skin), or intrathecally (into the fluid-filled space of the spinal canal) by a doctor or nurse in a medical facility.
What unique adverse effects are associated with cytarabine?
Cytarabine can cause serious side effects on your brain or central nervous system that may not be reversible.
- severe drowsiness, confusion, unusual thoughts or behavior;
- fever, chills, body aches, feeling very ill;
- stomach pain, bloating, nausea, vomiting, bloody or tarry stools;
How do you monitor cytarabine?
You will be checked regularly by your doctor while you are taking cytarabine, to monitor side effects and check your response to therapy. Periodic blood work to monitor your complete blood count (CBC), as well as the function of other organs (such as your kidneys and liver) will also be ordered by your doctor.
How do you infuse cytarabine?
Cytarabine, under strict medical surveillance, is administered as monotherapy or in combination with other cytostatics, 2-3 g/m2, as intravenous infusion, for 1-3 hours every 12 hours for 2-6 days. (Total of 12 doses per cycle). A total treatment dose of 36 g/m2 should not be exceeded.
Is cytarabine an antimetabolite?
Cytarabine is an antimetabolite and an antineoplastic agent that belongs to the category of drugs known as anthracyclines.
How do you give cytarabine injection?
Cytarabine 100 mg/ml Injection is a ready to use injection and can be administered by the intravenous and subcutaneous routes. Cytarabine 100 mg/ml Injection should not be administered by the intrathecal route due to the slight hypertonicity of this formulation.
How is Cytarabine stored?
CYTARABINE injection, powder, lyophilized, for solution: Solutions reconstituted with Bacteriostatic Water for Injection USP with benzyl alcohol may be stored at controlled room temperature, 15° to 30°C (59° to 86°F), for 48 hours. Discard any solutions in which a slight haze develops.
Where does Cytarabine come from?
The isolation of C-nucleosides from the Caribbean sponge, Cryptotheca crypta, four decades ago, provided the basis for the synthesis of cytarabine, the first marine-derived anticancer agent to be developed for clinical use. Cytarabine is currently used in the routine treatment of patients with leukaemia and lymphoma.
What should I know about liposomal cytarabine before taking it?
Before you begin treatment with liposomal cytarabine, you and your doctor should talk about the good this medicine will do as well as the risks of using it. Liposomal cytarabine is to be administered only by or under the immediate supervision of your doctor. Copyright © 2021 IBM Watson Health.
How do you administer Depo cyt?
DepoCyt is administered directly into the CSF via an intraventricular reservoir or by direct injection into the lumbar sac. DepoCyt should be injected slowly over a period of 1-5 minutes. Following drug administration by lumbar puncture, the patient should be instructed to lie flat for 1 hour.
What is the dilution for cytarabine injection?
Dilution of Conventional Cytarabine Cytarabine injection solution (containing 20 or 100 mg/mL) may be diluted with a compatible IV solution (e.g., 5% dextrose injection, 0.9% sodium chloride injection) for direct IV injection, rapid IV injection, or IV infusion.
What is the mechanism of action of cytarabine?
Cytarabine is a cell cycle phase-specific antineoplastic agent, affecting cells only during the S-phase of cell division. Intracellularly, cytarabine is converted into cytarabine-5’-triphosphate (ara-CTP), which is the active metabolite.