Is butalbital acidic or basic?
Butalbital is a very weakly acidic compound (based on its pKa). In humans, butalbital is involved in acetaminophen action pathway. Butalbital is a short to intermediate-acting barbiturate that reversibly depresses the activity of excitable tissues, including the central nervous system in a nonselective manner .
Is phenobarbital an acid or base?
Phenobarbital (5-ethyl-5-phenylbarbituric acid) is a weak acid with a molecular weight of 232.23 and low water solubility.
What is the pH of phenobarbital?
It contains a phenobarbital. Sodium phenobarbital is an odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3).
What is butabarbital used for?
Butabarbital is used to treat insomnia (trouble sleeping). It is also used before a surgical procedure to make a person sleep (be unconscious). Butabarbital belongs to the group of medicines called barbiturates. They act in the central nervous system (CNS) to slow down the nervous system.
Is butalbital a hypnotic?
Barbiturates exhibit muscle-relaxing and anti-anxiety properties 3 and they are capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. The sedative dose of butalbital in nontolerant individuals is 5-100 mg and the hypnotic dose is 100-200 mg.
Is phenobarbital an amine?
In addition, this agent inhibits glutamate induced depolarization. Phenobarbital is a barbiturate that is widely used as a sedative and an antiseizure medication….1.3Crystal Structures.
CCDC Number | 263169 |
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Crystal Structure Depiction | |
Associated Article | DOI:10.1107/S0108768104031143 |
How is phenobarbital influenced by pH?
It was found that acid pH values have little effect upon the solubility of phenobarbital as the alcohol concentration is increased; whereas, hydrogen ion concentrations of 10−7 to 10−10 do cause a marked increase.
How does pH affect phenobarbital?
Is butabarbital a controlled substance?
Butalbital is listed by the United States Drug Enforcement Agency as a Schedule III controlled substance, meaning that it has a moderate potential for abuse, the development of physical dependence, and addiction.
What is the Iupac name for butabarbital?
Butabarbital
Clinical data | |
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IUPAC name 5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione | |
CAS Number | 125-40-6 |
PubChem CID | 2479 |
IUPHAR/BPS | 7137 |
What is PKA and PK a?
If you’re working with acids and bases, two familiar values are pH and pKa. Here is the definition of pKa and a look at how it relates to acid strength. pK a is the negative base-10 logarithm of the acid dissociation constant (K a) of a solution.
What is butabarbital?
Butabarbital is a sedative hypnotic member of the barbiturate family. It is relatively fast acting, with a short duration, producing a range of effects from mild sedation to hypnosis as a function of dosage.
Is Butabarbital sodium a strong or weak acid?
Butabarbital sodium tablets and butabarbital sodium oral solution, is the sodium salt of a weak acid. Barbiturates are weak acids that are absorbed and rapidly distributed to all tissues and fluids with high concentrations in the brain, liver, and kidneys.
What is the PK a of acetic acid?
pKa Definition. pK a is the negative base-10 logarithm of the acid dissociation constant (K a) of a solution. The lower the pK a value, the stronger the acid. For example, the pKa of acetic acid is 4.8, while the pKa of lactic acid is 3.8.