Is subacute sclerosing panencephalitis rare?
Subacute sclerosing panencephalitis is a rare neurological disease of childhood or young adulthood.
What is the pathogenesis of subacute sclerosing panencephalitis?
Subacute sclerosing panencephalitis (SSPE) is a progressive fatal demyelinating disease caused by infection with high levels of neuronal measles virus (MV) in the CNS. Thus, MV infection provides one of the main paradigms of persistent viral infection that causes encephalitis.
How does measles cause subacute sclerosing panencephalitis?
Measles virus may cause immediate symptoms of brain infection (encephalitis. The spinal cord may also be involved… read more ), or the virus may remain in the brain for a long time without causing problems. Subacute sclerosing panencephalitis occurs because the measles virus reactivates.
Is subacute sclerosing panencephalitis a latent disease?
Subacute sclerosing panencephalitis (SSPE)—also known as Dawson disease—is a rare form of chronic, progressive brain inflammation caused by slow infection with certain defective strains of hypermutated measles virus….
Subacute sclerosing panencephalitis | |
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Prevention | Measles vaccine |
Treatment | Supportive treatment |
What is subacute sclerosing panencephalitis (SSPE)?
Subacute sclerosing panencephalitis (SSPE) is a subacute encephalopathy of childhood and young adolescence. Infrequently, SSPE can occur in adults and pregnant women.
How is the progression of SSPE graded?
The progression of the disease can be graded depending on the clinical presentation as given in CSF examination usually shows normal cellular and biochemical parameters with elevated protein levels. Subacute sclerosing panencephalitis (SSPE) is a late complication of childhood measles.
What are the initial manifestations of SSPE in schizophrenia?
tion, ca tatonic schizophr enia, and malingering [58]. ported as initial manifestations of SSPE. Because o f de- the clinical picture may simulat e schizophrenia [59–62]. diagnosis of funct ional illness. A diagnosis of SSPE was then made 9 months after disease onset [59]. cranial space occupying lesion. For example, SSPE was seizures.
What is the prognosis of SSPE?
In a few, the disease can p rogress very rapidly and lead to death within a few months. So far available treatments are disappoin ting. In develo ping countries, the situation is grim. SSPE is still very frequentl y en- countered. Combination of isoprinosine and intraven- tricular alpha-interferon is unaffor dable. N ovel thera-