What are RAG2 knockout mice?
Common Name: RAG2 KO. RAG2 knock-out mice produce no mature T cells or B cells. Their phenotype can be described as a “non-leaky” immune deficiency. These mice may be useful in the study of hematopoietic and immune system defects, cancer, toxicology, and xenograft/transplant studies.
What is meant by the term knockout mice?
A knockout mouse is a laboratory mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA.
What does Jackson Labs do?
The Jackson Laboratory is an independent, 501(c)3 nonprofit biomedical research institution founded in 1929 in Bar Harbor, Maine. Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
What is the difference between RAG1 and RAG2 knockout mice?
Unlike the binding of RAG1 plus RAG2, RAG1 can bind to DNA in the absence of a divalent metal ion and does not require the presence of coding flank sequence. Footprinting of the RAG1-RAG2 complex with 1,10-phenanthroline-copper and dimethyl sulfate protection reveal that both the heptamer and the nonamer are involved.
What does RAG1 and RAG2 do?
Abstract. The RAG1 and RAG2 proteins initiate V(D)J recombination by introducing double-strand breaks at the border between a recombination signal sequence (RSS) and a coding segment.
How is OncoMouse transgenic?
The OncoMouse or Harvard mouse is a type of laboratory mouse (Mus musculus) that has been genetically modified using modifications designed by Philip Leder and Timothy A Stewart of Harvard University to carry a specific gene called an activated oncogene (v-Ha-ras under the control of the mouse mammary tumor virus …
Is Jackson Laboratory good?
Is The Jackson Laboratory a good company to work for? The Jackson Laboratory has an overall rating of 3.7 out of 5, based on over 304 reviews left anonymously by employees.
Is the Jackson Laboratory reliable?
The Jackson Laboratory is recognized by the IRS as a public charity. According to organization literature, revenue comes primarily from the sale of materials and services (~70%) and from government support (~25%).
What is a Super mouse?
Supermouse, a mouse with superpowers who appears in comic books published by Standard Comics. Super Mouse was also the original name of Mighty Mouse.
What is the knockout mouse project?
The Knockout Mouse Project (KOMP) is providing critical tools for understanding gene function and the genetic causes of human diseases. Coordinated by the International Mouse Phenotyping Consortium (IMPC), an international coalition will produce and phenotype a total of 5,000 knockout mice by 2016.
What is a Jax mouse?
JAX® Mice & Services. JAX® Mice are the highest quality and most-published mouse models in the world. Take advantage of our large inventories of common inbred strains and the convenience of having your breeding and drug efficacy needs met by the leading experts in mouse modeling.
What is a 6neo mouse?
These Gaa knock-out mice, commonly called 6neo or PD mice, exhibit a progressive accumulation of lysosomal glycogen in heart and skeletal muscle, and diaphragm with reduced mobility and progressive muscle weakness that is associated with Pompe disease.
Why use knock-out mice for hemophilia A?
These knock-out mice are deficient of endogenous Factor VIII making them useful for hemophilia A studies. Mice that are homozygous for the targeted, X chromosome-linked mutant allele are viable and fertile. Homozygous females and carrier males have less than 1% of normal factor VIII activity and exhibit prolonged clotting times.
