What class of drug is conivaptan?
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin).
What is conivaptan used for?
Conivaptan injection is used to treat euvolemic hyponatremia (a condition where there is not enough sodium in your blood but with a normal blood volume). Sodium is a chemical that the body needs to be able to function well.
What is the mechanism of action of conivaptan?
Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). Conivaptan is a Vasopressin Receptor Antagonist. The mechanism of action of conivaptan is as a Vasopressin Receptor Antagonist, and Cytochrome P450 3A Inhibitor.
How is conivaptan given?
Conivaptan is given intravenously with a bolus of 20 mg over 30 minutes in 100 mL of 5% dextrose in water (D5W) followed by a continuous infusion of 20 mg conivaptan diluted in 250 mL of D5W over 24 hours. After the initial day of treatment, conivaptan can be continued for an additional 1 to 3 days.
What do Vaptans do?
The vaptans constitute a new class of pharmaceuticals developed for the treatment of the hypervolemic and euvolemic forms of hyponatremia. These agents are nonpeptide vasopressin antagonists that interfere with the antidiuretic effect of the hormone by competitively binding to V(2) receptors in the kidney.
What is vaprisol used for?
Conivaptan reduces the level of a hormone that regulates the balance of water and salt (sodium) in the body. High levels of this hormone can cause an imbalance that results in low sodium levels and fluid retention. Conivaptan is used to treat hyponatremia (low sodium levels).
When should I take Conivaptan?
Conivaptan is used to treat hyponatremia (low sodium levels). Conivaptan improves urine flow without causing the body to lose too much sodium as you urinate. Conivaptan may also be used for purposes not listed in this medication guide.
How does Conivaptan treat hyponatremia?
Conivaptan in the treatment of hyponatremia Antagonism of the V2 receptor increases free water excretion causing hypo-osmolar urine, enhanced diuresis, and increased plasma [Na+] levels. Several animal studies have demonstrated the aquaretic effect of conivaptan (Table 4).
When should I take conivaptan?
How does conivaptan treat hyponatremia?
Where do Vaptans work?
Abstract. The vaptans constitute a new class of pharmaceuticals developed for the treatment of the hypervolemic and euvolemic forms of hyponatremia. These agents are nonpeptide vasopressin antagonists that interfere with the antidiuretic effect of the hormone by competitively binding to V(2) receptors in the kidney.