What does spectinomycin treat in dogs?
EXPLANATION Spectinomycin is an aminocyclitol antibiotic produced by Streptomyces spectabilis. It is used in human medicine for the treatment of uncomplicated gonorrhoea. In veterinary medicine spectinomycin is used therapeutically for bacterial respiratory and enteric infections.
What class of antibiotic is spectinomycin?
It is in aminocyclitol class, closely related to the aminoglycosides. Spectinomycin is industrially produced by fermentation of the bacterium Streptomyces spectabilis.
Is spectinomycin bacteriostatic?
Since spectinomycin is purely bacteriostatic and stabilizes polysomes, it must block resistant ribosomes behind inhibited sensitive ribosomes; hence, these results are consistent with an initial similar polysomal blockade by streptomycin.
Can dogs have spectinomycin?
(c) Conditions of use in dogs—(1) Amount. Administer orally to provide 10 mg per pound (lb) of body weight twice daily. Dosage may be continued for 4 consecutive days.
What does spectinomycin do to bacteria?
Spectinomycin binds to the bacterial 30S ribosomal subunit. As a result, this agent interferes with the initiation of protein synthesis and with proper protein elongation. This eventually leads to bacterial cell death.
Is spectinomycin available in the US?
No other pharmaceutical company manufactures or sells spectinomycin in the United States. Pfizer is continuing to distribute spectinomycin outside the United States for the international market.
Are ampicillin and carbenicillin the same?
The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes, although they are more resistant than ampicillin to degradation. Carbenicillin is also more stable at lower pH than ampicillin.
What is spectinomycin sulfate?
Spectinomycin Sulfate is the sulfate salt form of spectinomycin, an aminocyclitol aminoglycoside antibiotic derived from Streptomyces spectabilis with bacteriostatic activity. Spectinomycin binds to the bacterial 30S ribosomal subunit.
How long does spectinomycin sulphate tetrahydrate need to stand at room temperature?
Spectinomycin sulphate tetrahydrate for veterinary useEUROPEAN PHARMACOPOEIA 6.0 Allow the solution to stand at room temperature for not less than 30 min and not more than 2 h prior to determination. Related substances. Liquid chromatography (2.2.29).
What is the content of 4R dihydrospectinomycin sulphate?
Content: —(4R)-dihydrospectinomycin sulphate: maximum 2.0 per cent (anhydrous substance); —sum of the contents of spectinomycin sulphate and (4R)-dihydrospectinomycin sulphate: 93.0 per cent to 102.0 per cent (anhydrous substance). CHARACTERS Appearance:whiteoralmostwhitepowder.
What are the possible side effects of streptomycin toxicity in infants?
CNS depression (e.g., stupor, flaccidity, coma, deep respiratory depression) reported in very young infants receiving streptomycin dosage exceeding the recommended maximum dosage. Select dosage with caution and closely monitor renal function because of age-related decreases in renal function.