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What does V1 receptor do?

Table of Contents

  • What does V1 receptor do?
  • What type of receptors are V1 and V2?
  • What is argipressin used for?
  • What type of receptor is V1?
  • What is the effect of AVP on V1 receptor?

What does V1 receptor do?

The V1 receptor stimulates vascular smooth muscle contraction, resulting in the vasopressor response of AVP. The V2 receptors primarily act in the kidney to produce water retention (antidiuretic hormone), and the V3 receptors act in the central nervous system, and modulate corticotropin secretion.

What is the difference between V1 and V2 receptors?

These are two major types of vasopressin receptors: V1 & V2. The V1 receptors are located on blood vessels and are responsible for the vasopressor action. The V2 receptors are in the basolateral membrane of the collecting tubule cells in the kidney.

What type of receptors are V1 and V2?

Three subtypes of vasopressin receptors, V1, V2, and V3, have been identified (table 1). V1 receptors are found on various cells including vascular smooth muscle, and V1 stimulation causes vasoconstriction. Kidney collecting duct cells express V2 receptors, which mediate water retention.

What type of receptor is v1?

V1 receptor V1 receptors (V1Rs) are found in high density on vascular smooth muscle and cause vasoconstriction by an increase in intracellular calcium via the phosphatidyl–inositol-bisphosphate cascade.

What is argipressin used for?

Argipressin is used to treat: – diabetes insipidus. This is a rare form of diabetes causing production of large quantities of urine. Argipressin increases the amount of water absorbed back into your kidneys. – bleeding from enlarged veins in the oesophagus (food pipe).

Does ADH cause vasoconstriction?

However, ADH at high concentrations causes vasoconstriction, thus raising blood pressure. Increased water retention due to ADH can result in the following conditions: Concentrated urine. Increased plasma volume.

What type of receptor is V1?

Does vasopressin cause vasoconstriction?

Vasopressin is also capable of causing vasoconstriction and increasing blood pressure. This action is mediated by vascular V1-receptors, which, unlike the renal receptors, are coupled to phospholipase C and increased intracellular Ca2+ concentration.

What is the effect of AVP on V1 receptor?

The V1 Receptor AVP binding to the receptor causes activation of Gq/11-mediated phospholipase C, resulting in an increase in intracellular calcium. Binding of AVP to V1 receptors at physiologic plasma concentrations has been shown to exert a weak pressor effect.

Where are V1 and V2 receptors located?

Subtypes

Subtype (symbol) Location
gene receptor
AVPR1A V1A vascular smooth muscle, platelet, hepatocytes, myometrium
AVPR1B V1B anterior pituitary gland
AVPR2 V2 basolateral membrane of collecting duct, vascular endothelium and vascular smooth muscle cell

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