What drug class is aztreonam?
Aztreonam is in a class of medications called monobactam antibiotics. It works by killing bacteria.
Is aztreonam a penicillin?
Aztreonam is a monobactam antibiotic that was approved in 1986 for the treatment of Gram-negative bacterial infections via intravenous or intramuscular injection (Azactam®) . This drug was marketed to treat bacterial infections and is safe for patients with penicillin allergies .
Is aztreonam an aminoglycoside?
Abstract. The aminoglycosides continue to be the cornerstone of antibiotic therapy for serious infections caused by gram-negative aerobic pathogens, even with the recent introduction of potent beta-lactams and the fluoroquinolones. Two of these newer agents are imipenem and aztreonam.
Is aztreonam a carbapenem?
Imipenem (a carbapenem) is active against essentially all pathogenic organisms, but aztreonam (a monobactam) is active against only aerobic gram-negative bacilli.
How does chloramphenicol work?
Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.
What is another name for aztreonam?
Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa.
What antibiotics are in the tetracycline family?
Tetracyclines (tetracycline, doxycycline, minocycline, tigecycline) are a class of medication used to manage and treat various bacterial infections. Tetracyclines classify as protein synthesis inhibitor antibiotics and are considered to be broad-spectrum.
Can you give aztreonam in penicillin allergy?
A frequent clinical question is whether these patients can safely receive the structurally related cephalosporins or carbapenems (monobactams [ie, aztreonam] are not cross-reactive with penicillins and can be safely given to penicillin-allergic patients).
Is cefotaxime a cephalosporin?
Cefotaxime, ceftazidime and ceftriaxone are ‘third generation’ cephalosporins with greater activity than the ‘second generation’ cephalosporins against certain Gram-negative bacteria.
What are carbapenem drugs?
Carbapenems are part of a class of antibiotics called beta-lactam antibiotics. Carbapenems have a broad spectrum of activity and are often used to treat severe infections, including multi-drug-resistant serious infections caused by bacteria.
What family is meropenem in?
It is in the carbapenem family of medications. Meropenem usually results in bacterial death through blocking their ability to make a cell wall.
Is chloramphenicol a strong antibiotic?
Chloramphenicol is a broad spectrum antibiotic introduced into clinical practice in 1948, but which was subsequently shown to cause serious and fatal aplastic anemia and is now used rarely and reserved for severe, life-threatening infections for which other antibiotics are not available.
What type of drug is aztreonam?
It is in the monobactam family of medications. Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. Aztreonam was approved for medical use in the United States in 1986.
Can aztreonam cause anaphylaxis?
However, like other beta lactams, there is a risk of very serious allergic reactions, including anaphylaxis. The aztreonam label directs physicians to be aware of the possibility of these severe adverse reactions. This is more likely if the patient is allergic to a certain cephalosporin known as ceftazidime.
How does aztreonam affect the excretion of other medications?
Aztreonam may decrease the excretion rate of Glipizide which could result in a higher serum level. Aztreonam may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level. Aztreonam may decrease the excretion rate of Golodirsen which could result in a higher serum level.
What is the half life of aztreonam in patients with impaired renal function?
In patients with impaired renal function, the serum half-life of Aztreonam is prolonged (see DOSAGE AND ADMINISTRATION, Renal Impairment in Adult Patients). The serum half-life of Aztreonam is only slightly prolonged in patients with hepatic impairment since the liver is a minor pathway of excretion.