What is a high IgG synthesis rate?
Cerebrospinal fluid (CSF) IgG synthesis rate indicates the rate of increase in the daily CSF production of IgG in milligrams per day. A result greater than 12 mg/24 hours is elevated. A CSF index greater than 0.85 is elevated and indicative of increased synthesis of IgG.
What is IgG ratio?
0.43 is the molecular weight ratio of albumin: IgG and 5 is the daily CSF production expressed in dL. The reference interval is –9.9 to +3.3 mg per day. Negative values are considered normal….Multiple Sclerosis Panel.
| Test | Reference Range |
|---|---|
| IgG/Albumin ratio | 0.066 – 0.270 |
| IgG index | 0.0 – 0.7 mg/dL |
| Oligoclonal bands | Absent |
What does intrathecal IgG synthesis mean?
Intrathecal IgG synthesis is a key biological feature of multiple sclerosis (MS). When acquired early, it persists over time. A growing body of evidence suggests that intrathecal Ig-secreting cells may be pathogenic either by a direct action of toxic IgG or by locally secreting bystander toxic products.
What is intrathecal synthesis of IgG?
What is a high level of IgG Covid antibodies?
Strong positive (≥200 IU/mL): IgG antibody values at and greater than 200 IU/mL confirm the presence of high levels of circulating IgG antibodies binding to the Spike protein of SARS-CoV-2.
What does it mean if your Covid IgG is high?
The presence of IgG suggests that the infection happened weeks to months in the past. It also suggests that you may no longer be infectious. IgG indicates that you may have some immunity to the virus, though you may not. How much it might protect you from getting sick with COVID-19 in the future is unknown.
What diseases cause Oligoclonal bands in CSF?
Oligoclonal bands in CSF have been reported in cases of neurosyphilis, acute bacterial or viral meningitis, progressive multifocal leukoencephalopathy, subacute sclerosing panencephalitis, progressive rubella panencephalitis, polyneuritis, optic neuritis, trypanosomiasis, and other infectious or autoimmune diseases.
