What is an adverse effect of gemfibrozil?
Many people using this medication do not have serious side effects. This medication may rarely cause gallstones and liver problems. Tell your doctor right away if you notice any of these serious side effects: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine.
What happens if you take too much LOPID?
In one case, a 7-year-old child recovered after ingesting up to 9 grams of LOPID. Symptoms reported with overdosage were abdominal cramps, abnormal liver function tests, diarrhea, increased CPK, joint and muscle pain, nausea and vomiting. Symptomatic supportive measures should be taken, should an overdose occur.
What are the contraindications of gemfibrozil?
Contraindications for using gemfibrozil include hepatic or severe renal dysfunction (including primary biliary cirrhosis), presence of cholelithiasis, gallbladder abnormalities, hypersensitivity, and combination therapy of gemfibrozil with the following drugs: simvastatin, repaglinide, or dasabuvir.
What are the expected side effects of fibric acid derivatives?
The side effects of fibrates include nausea, stomach upset, and sometimes diarrhea. Fibrates can irritate (inflame) the liver. The liver irritation usually is mild and reversible, but it occasionally can be severe enough to require stopping the drug. Fibrates can cause gallstones when used for several years.
What is Lopid used to treat?
Gemfibrozil is used along with a proper diet to help lower fats (triglycerides) and raise “good” cholesterol (HDL) in the blood. It may also help to lower “bad” cholesterol (LDL). Gemfibrozil belongs to a group of drugs known as “fibrates.” It works by decreasing the amount of fat produced by the liver.
What is the drug Lopid used for?
What are the side effects of fibrates?
Like all medications, some people may experience side effects after taking fibrates….Fibrates may cause:
- Abdominal pain.
- Leg cramps.
What is the mechanism of action and side effects of the fibric acid derivatives?
Mechanism of action Fibrates reduce hepatic triglyceride levels by inhibiting hepatic extraction of free fatty acids and thus hepatic triglyceride production. These drugs may also lower cholesterol by increasing endothelial lipoprotein lipase activity.
What is the indication for Lopid?
LOPID (gemfibrozil tablets, USP) is indicated as adjunctive therapy to diet for: 1. Treatment of adult patients with very high elevations of serum triglyceride levels (Types IV and V hyperlipidemia) who present a risk of pancreatitis and who do not respond adequately to a determined dietary effort to control them.